{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yildirim C"],"funding":["Eunice Kennedy Shriver National Institute of Child Health and Human Development","NICHD NIH HHS","Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)","NIMH NIH HHS","National Institute of Mental Health"],"pagination":["2109-2120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6650348"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(8)"],"pubmed_abstract":["Antiretroviral (ARV) adherence is critical in monitoring disease response in youth with perinatally-acquired HIV (PHIV). We used pharmacy refill (PR) information for PHIV youth from the PHACS Memory Sub-study to calculate medication availability over 2, 4, and 6 months. PR, a proxy of adherence, was compared with self-reported 7-day adherence in predicting suppressed viral load (SVL < 400 copies/mL) and higher CD4% (≥ 25%). Among 159 PHIV youth, 79% were adherent by 7-day recall, and 62, 55, and 48% by PR over 2, 4, and 6 months, respectively. Agreement between 7-day recall and PR adherence was weak (Kappa = 0.09-0.25). In adjusted logistic regression models, adherence showed associations with SVL for 7-day recall (OR 2.78, 95% CI 1.08, 7.15) and all PR coverage periods (6-month: OR 3.24, "],"journal":["AIDS and behavior"],"pubmed_title":["The Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV)."],"pmcid":["PMC6650348"],"funding_grant_id":["MH084794","HD052102 / HD052104","R01 MH084794","U01 HD052102","U01 HD052104"],"pubmed_authors":["Allison K","Baig M","Paul M","McFarland E","Hunter S","Bettica L","Patton ED","Rios H","Paul S","Cooper N","Katai A","Nozyce M","Wilkins M","Nichols SL","Bryan P","Shearer W","Purswani M","Chen J","Karthas N","Jones M","Williams PL","Acevedo-Flores M","Yildirim C","Dunn J","Burey M","Wiznia A","Spector S","Scott G","Chernoff M","Memory and Executive Functioning Study of the Pediatric HIV/AIDS Cohort Study","Dieudonne A","Grant M","Sirois P","Olivera V","Bulkley MG","Garvie PA","Burchett S","Norris K","Knapp K","Yogev R","Navarro A","Willen E","Garvie P","Malee K","Adubato S","Nichols S","Ivey L","Sanders MA","Wilkins ML","Blood J","Cintron A","Kammerer B","Silio M","Harris L"],"additional_accession":[]},"is_claimable":false,"name":"The Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV).","description":"Antiretroviral (ARV) adherence is critical in monitoring disease response in youth with perinatally-acquired HIV (PHIV). We used pharmacy refill (PR) information for PHIV youth from the PHACS Memory Sub-study to calculate medication availability over 2, 4, and 6 months. PR, a proxy of adherence, was compared with self-reported 7-day adherence in predicting suppressed viral load (SVL < 400 copies/mL) and higher CD4% (≥ 25%). Among 159 PHIV youth, 79% were adherent by 7-day recall, and 62, 55, and 48% by PR over 2, 4, and 6 months, respectively. Agreement between 7-day recall and PR adherence was weak (Kappa = 0.09-0.25). In adjusted logistic regression models, adherence showed associations with SVL for 7-day recall (OR 2.78, 95% CI 1.08, 7.15) and all PR coverage periods (6-month: OR 3.24, ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2025-04-04T02:10:55.378Z","creation":"2020-10-30T08:33:41Z"},"accession":"S-EPMC6650348","cross_references":{"pubmed":["30929147"],"doi":["10.1007/s10461-019-02468-x"]}}