biostudies-literatureYildirim CEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNICHD NIH HHSEunice Kennedy Shriver National Institute of Child Health and Human Development (US)NIMH NIH HHSNational Institute of Mental Health2109-2120https://www.ebi.ac.uk/biostudies/studies/S-EPMC6650348biostudies-literatureUnknown23(8)Antiretroviral (ARV) adherence is critical in monitoring disease response in youth with perinatally-acquired HIV (PHIV). We used pharmacy refill (PR) information for PHIV youth from the PHACS Memory Sub-study to calculate medication availability over 2, 4, and 6 months. PR, a proxy of adherence, was compared with self-reported 7-day adherence in predicting suppressed viral load (SVL < 400 copies/mL) and higher CD4% (≥ 25%). Among 159 PHIV youth, 79% were adherent by 7-day recall, and 62, 55, and 48% by PR over 2, 4, and 6 months, respectively. Agreement between 7-day recall and PR adherence was weak (Kappa = 0.09-0.25). In adjusted logistic regression models, adherence showed associations with SVL for 7-day recall (OR 2.78, 95% CI 1.08, 7.15) and all PR coverage periods (6-month: OR 3.24, AIDS and behaviorThe Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV).PMC6650348MH084794HD052102 / HD052104R01 MH084794U01 HD052102U01 HD052104Allison KBaig MPaul MMcFarland EHunter SBettica LPatton EDRios HPaul SCooper NKatai ANozyce MWilkins MNichols SLBryan PShearer WPurswani MChen JKarthas NJones MWilliams PLAcevedo-Flores MYildirim CDunn JBurey MWiznia ASpector SScott GChernoff MMemory and Executive Functioning Study of the Pediatric HIV/AIDS Cohort StudyDieudonne AGrant MSirois POlivera VBulkley MGGarvie PABurchett SNorris KKnapp KYogev RNavarro AWillen EGarvie PMalee KAdubato SNichols SIvey LSanders MAWilkins MLBlood JCintron AKammerer BSilio MHarris LfalseThe Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV).Antiretroviral (ARV) adherence is critical in monitoring disease response in youth with perinatally-acquired HIV (PHIV). We used pharmacy refill (PR) information for PHIV youth from the PHACS Memory Sub-study to calculate medication availability over 2, 4, and 6 months. PR, a proxy of adherence, was compared with self-reported 7-day adherence in predicting suppressed viral load (SVL < 400 copies/mL) and higher CD4% (≥ 25%). Among 159 PHIV youth, 79% were adherent by 7-day recall, and 62, 55, and 48% by PR over 2, 4, and 6 months, respectively. Agreement between 7-day recall and PR adherence was weak (Kappa = 0.09-0.25). In adjusted logistic regression models, adherence showed associations with SVL for 7-day recall (OR 2.78, 95% CI 1.08, 7.15) and all PR coverage periods (6-month: OR 3.24, 2019-01-01T00:00:00Z2019 Aug2025-04-04T02:10:55.378Z2020-10-30T08:33:41ZS-EPMC66503483092914710.1007/s10461-019-02468-x