{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Misumi I"],"funding":["NIDDK NIH HHS","NCI","NIAID NIH HHS","Pilot & Feasibility","Nutrition Obesity Research Center","NCI NIH HHS","NIH","UNC-CH"],"pagination":["514-524.e5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6652206"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(2)"],"pubmed_abstract":["Obesity in humans is associated with poorer health outcomes after infections compared with non-obese individuals. Here, we examined the effects of white adipose tissue and obesity on T cell responses to viral infection in mice. We show that lymphocytic choriomeningitis virus (LCMV) grows to high titer in adipose tissue. Virus-specific T cells enter the adipose tissue to resolve infection but then remain as a memory population distinct from memory T cells in lymphoid tissues. Memory T cells in adipose tissue are abundant in lean mice, and diet-induced obesity further increases memory T cell number in adipose tissue and spleen. Upon re-challenge infection, memory T cells rapidly cause severe pathogenesis, leading to increases in lipase levels, calcification of adipose tissue, pancreatitis, a"],"journal":["Cell reports"],"pubmed_title":["Obesity Expands a Distinct Population of T Cells in Adipose Tissue and Increases Vulnerability to Infection."],"pmcid":["PMC6652206"],"funding_grant_id":["R56 AI110682","P30 DK056350","P30CA016086","P30 CA016086","R01AI138337","R56AI110682","R01 AI138337","R21 AI117575","R21AI117575","R01-GM10974","P30DK56350"],"pubmed_authors":["Beck MA","Uchimura T","Magnuson T","Whitmire JK","Misumi I","Starmer J"],"additional_accession":[]},"is_claimable":false,"name":"Obesity Expands a Distinct Population of T Cells in Adipose Tissue and Increases Vulnerability to Infection.","description":"Obesity in humans is associated with poorer health outcomes after infections compared with non-obese individuals. Here, we examined the effects of white adipose tissue and obesity on T cell responses to viral infection in mice. We show that lymphocytic choriomeningitis virus (LCMV) grows to high titer in adipose tissue. Virus-specific T cells enter the adipose tissue to resolve infection but then remain as a memory population distinct from memory T cells in lymphoid tissues. Memory T cells in adipose tissue are abundant in lean mice, and diet-induced obesity further increases memory T cell number in adipose tissue and spleen. Upon re-challenge infection, memory T cells rapidly cause severe pathogenesis, leading to increases in lipase levels, calcification of adipose tissue, pancreatitis, a","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Apr","modification":"2026-05-07T05:16:28.121Z","creation":"2019-07-30T07:09:19Z"},"accession":"S-EPMC6652206","cross_references":{"pubmed":["30970254"],"doi":["10.1016/j.celrep.2019.03.030"]}}