biostudies-literatureMisumi INIDDK NIH HHSNCINIAID NIH HHSPilot & FeasibilityNutrition Obesity Research CenterNCI NIH HHSNIHUNC-CH514-524.e5https://www.ebi.ac.uk/biostudies/studies/S-EPMC6652206biostudies-literatureUnknown27(2)Obesity in humans is associated with poorer health outcomes after infections compared with non-obese individuals. Here, we examined the effects of white adipose tissue and obesity on T cell responses to viral infection in mice. We show that lymphocytic choriomeningitis virus (LCMV) grows to high titer in adipose tissue. Virus-specific T cells enter the adipose tissue to resolve infection but then remain as a memory population distinct from memory T cells in lymphoid tissues. Memory T cells in adipose tissue are abundant in lean mice, and diet-induced obesity further increases memory T cell number in adipose tissue and spleen. Upon re-challenge infection, memory T cells rapidly cause severe pathogenesis, leading to increases in lipase levels, calcification of adipose tissue, pancreatitis, aCell reportsObesity Expands a Distinct Population of T Cells in Adipose Tissue and Increases Vulnerability to Infection.PMC6652206R56 AI110682P30 DK056350P30CA016086P30 CA016086R01AI138337R56AI110682R01 AI138337R21 AI117575R21AI117575R01-GM10974P30DK56350Beck MAUchimura TMagnuson TWhitmire JKMisumi IStarmer JfalseObesity Expands a Distinct Population of T Cells in Adipose Tissue and Increases Vulnerability to Infection.Obesity in humans is associated with poorer health outcomes after infections compared with non-obese individuals. Here, we examined the effects of white adipose tissue and obesity on T cell responses to viral infection in mice. We show that lymphocytic choriomeningitis virus (LCMV) grows to high titer in adipose tissue. Virus-specific T cells enter the adipose tissue to resolve infection but then remain as a memory population distinct from memory T cells in lymphoid tissues. Memory T cells in adipose tissue are abundant in lean mice, and diet-induced obesity further increases memory T cell number in adipose tissue and spleen. Upon re-challenge infection, memory T cells rapidly cause severe pathogenesis, leading to increases in lipase levels, calcification of adipose tissue, pancreatitis, a2019-01-01T00:00:00Z2019 Apr2026-05-07T05:16:28.121Z2019-07-30T07:09:19ZS-EPMC66522063097025410.1016/j.celrep.2019.03.030