biostudies-literatureAllen JHHS | NIH | National Institute of Allergy and Infectious Diseasese00262-19https://www.ebi.ac.uk/biostudies/studies/S-EPMC6652777biostudies-literatureUnknown87(8)It has been shown that caspase-1, but not its upstream activator, ASC, contributes to oviduct pathology during mouse genital Chlamydia muridarum infection. We hypothesized that this dichotomy is due to the inadvertent absence of caspase-11 in previously used caspase-1-deficient mice. To address this, we studied the independent contributions of caspase-1 and -11 during genital Chlamydia infection. Our results show that caspase-11 deficiency was sufficient to recapitulate the effect of the combined absence of both caspase-1 and caspase-11 on oviduct pathology. Further, mice that were deficient for both caspase-1 and -11 but that expressed caspase-11 as a transgene (essentially, caspase-1-deficient mice) had no significant difference in oviduct pathology from control mice. Caspase-11-deficienInfection and immunityCaspase-11 Contributes to Oviduct Pathology during Genital Chlamydia Infection in Mice.PMC6652777AI067678Gyorke CEAllen JTripathy MKZhang YMontgomery SALovett ANagarajan UMfalseCaspase-11 Contributes to Oviduct Pathology during Genital Chlamydia Infection in Mice.It has been shown that caspase-1, but not its upstream activator, ASC, contributes to oviduct pathology during mouse genital Chlamydia muridarum infection. We hypothesized that this dichotomy is due to the inadvertent absence of caspase-11 in previously used caspase-1-deficient mice. To address this, we studied the independent contributions of caspase-1 and -11 during genital Chlamydia infection. Our results show that caspase-11 deficiency was sufficient to recapitulate the effect of the combined absence of both caspase-1 and caspase-11 on oviduct pathology. Further, mice that were deficient for both caspase-1 and -11 but that expressed caspase-11 as a transgene (essentially, caspase-1-deficient mice) had no significant difference in oviduct pathology from control mice. Caspase-11-deficien2019-01-01T00:00:00Z2019 Aug2025-04-04T21:27:58.479Z2025-04-04T21:27:58.479ZS-EPMC66527773116036310.1128/IAI.00262-1910.1128/iai.00262-19