biostudies-literature00470Teng QFundamental Research Fund of Shandong UniversityNational Natural Science Foundation of China6863-6867https://www.ebi.ac.uk/biostudies/studies/S-EPMC6657412biostudies-literatureUnknown10(28)A rhodium-catalyzed highly regio- and enantioselective hydroalkynylation, generating <i>cis</i>-hydrobenzofuranone-tethered enynes has been developed. The reaction proceeds with a selective head-to-head insertion and symmetry breaking Michael addition cascade. One product was produced from tens of possible isomers through precise control of chemo-, regio-, and stereoselectivities using a single rhodium catalyst. Notable features of this method include 100% atom-economy, mild reaction conditions and a very broad substrate scope.Chemical scienceHydroalkynylative cyclization of 1,6-enynes with terminal alkynes.PMC665741221572118Teng QThirupathi NTung CHXu Z47falseHydroalkynylative cyclization of 1,6-enynes with terminal alkynes.A rhodium-catalyzed highly regio- and enantioselective hydroalkynylation, generating <i>cis</i>-hydrobenzofuranone-tethered enynes has been developed. The reaction proceeds with a selective head-to-head insertion and symmetry breaking Michael addition cascade. One product was produced from tens of possible isomers through precise control of chemo-, regio-, and stereoselectivities using a single rhodium catalyst. Notable features of this method include 100% atom-economy, mild reaction conditions and a very broad substrate scope.2019-01-01T00:00:00Z2019 Jul2024-10-18T15:04:57.749Z2019-08-12T07:03:14ZS-EPMC66574123139190910.1039/c9sc02341k