biostudies-literatureUnknown20(1)Boltz TA<h4>Background</h4>Histone deacetylases (HDACs) are the proteins responsible for removing the acetyl group from lysine residues of core histones in chromosomes, a crucial component of gene regulation. Eleven known HDACs exist in humans and most other vertebrates. While the basic function of HDACs has been well characterized and new discoveries are still being made, the transcriptional regulation of their corresponding genes is still poorly understood.<h4>Results</h4>Here, we conducted a computational analysis of the eleven HDAC promoter sequences in 25 vertebrate species to determine whether transcription factor binding sites (TFBSs) are conserved in HDAC evolution, and if so, whether they provide useful information about HDAC expression and function. Furthermore, we used tissue-specific iBMC genomics613https://www.ebi.ac.uk/biostudies/studies/S-EPMC6660948biostudies-literaturePromoter conservation in HDACs points to functional implications.PMC6660948Khuri SWuchty SBoltz TAfalsePromoter conservation in HDACs points to functional implications.<h4>Background</h4>Histone deacetylases (HDACs) are the proteins responsible for removing the acetyl group from lysine residues of core histones in chromosomes, a crucial component of gene regulation. Eleven known HDACs exist in humans and most other vertebrates. While the basic function of HDACs has been well characterized and new discoveries are still being made, the transcriptional regulation of their corresponding genes is still poorly understood.<h4>Results</h4>Here, we conducted a computational analysis of the eleven HDAC promoter sequences in 25 vertebrate species to determine whether transcription factor binding sites (TFBSs) are conserved in HDAC evolution, and if so, whether they provide useful information about HDAC expression and function. Furthermore, we used tissue-specific i2019-01-01T00:00:00Z2019 Jul2025-04-04T09:46:10.727Z2019-08-07T07:07:33ZS-EPMC66609483135146410.1186/s12864-019-5973-x