{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Trujillo-Gonzalez I"],"funding":["National Institute of Diabetes and Digestive and Kidney Diseases","NIDDK NIH HHS","NIEHS NIH HHS","NCI NIH HHS","National Institutes of Health","Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill"],"pagination":["9194-9209"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6662989"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(8)"],"pubmed_abstract":["Adequate supply of choline, an essential nutrient, is necessary to support proper brain development. Whether prenatal choline availability plays a role in development of the visual system is currently unknown. In this study, we addressed the role of <i>in utero</i> choline supply for the development and later function of the retina in a mouse model. We lowered choline availability in the maternal diet during pregnancy and assessed proliferative and differentiation properties of retinal progenitor cells (RPCs) in the developing prenatal retina, as well as visual function in adult offspring. We report that low choline availability during retinogenesis leads to persistent retinal cytoarchitectural defects, ranging from focal lesions with displacement of retinal neurons into subretinal space t"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["Low availability of choline <i>in utero</i> disrupts development and function of the retina."],"pmcid":["PMC6662989"],"funding_grant_id":["P30 DK056350","DK115380","DK056350","P30 CA016086","P30 ES010126","R01 DK115380"],"pubmed_authors":["Friday WB","Alam NM","Sha W","Trujillo-Gonzalez I","Weiss ER","Bachleda A","Munson CA","Zeisel SH","Surzenko N"],"additional_accession":[]},"is_claimable":false,"name":"Low availability of choline <i>in utero</i> disrupts development and function of the retina.","description":"Adequate supply of choline, an essential nutrient, is necessary to support proper brain development. Whether prenatal choline availability plays a role in development of the visual system is currently unknown. In this study, we addressed the role of <i>in utero</i> choline supply for the development and later function of the retina in a mouse model. We lowered choline availability in the maternal diet during pregnancy and assessed proliferative and differentiation properties of retinal progenitor cells (RPCs) in the developing prenatal retina, as well as visual function in adult offspring. We report that low choline availability during retinogenesis leads to persistent retinal cytoarchitectural defects, ranging from focal lesions with displacement of retinal neurons into subretinal space t","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2026-05-02T16:24:58.652Z","creation":"2021-02-20T06:47:31Z"},"accession":"S-EPMC6662989","cross_references":{"pubmed":["31091977"],"doi":["10.1096/fj.201900444R","10.1096/fj.201900444r"]}}