{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Larsen V"],"funding":["Breast Cancer Research Foundation","Susan G. Komen Foundation","NCI NIH HHS","National Institutes of Health","NIH"],"pagination":["225-235.e2"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6667288"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(4)"],"pubmed_abstract":["<h4>Introduction</h4>GATA3 is a critical transcription factor in maintaining the differentiated state of luminal mammary epithelial cells. We sought to determine the prognostic and predictive roles of GATA3 genotypes for breast cancer.<h4>Patients and methods</h4>Twelve single nucleotide polymorphisms (SNPs) were genotyped in 2 breast cancer cohorts, including the SWOG S8897 trial where patients were treated with adjuvant chemotherapy (CAF [cyclophosphamide, doxorubicin, 5-fluorouracil] vs. CMF [cyclophosphamide, methotrexate, 5-fluorouracil]) or untreated, and the observational Pathways Study.<h4>Results</h4>In the S8897 trial, rs3802604 and rs568727 were associated with disease-free survival and overall survival in the treated group, regardless of chemotherapy regimen. The GG genotype of"],"journal":["Clinical breast cancer"],"pubmed_title":["Germline Genetic Variants in GATA3 and Breast Cancer Treatment Outcomes in SWOG S8897 Trial and the Pathways Study."],"pmcid":["PMC6667288"],"funding_grant_id":["UG1 CA189821","U10 CA180819","P30 CA016056","UG1 CA189830","R01 CA105274","U01 CA195565","U10 CA180801","UG1 CA233160","U10 CA180888","U24 CA171524"],"pubmed_authors":["Ravdin PM","Roh JM","Hortobagyi GN","Osborne CK","Hutchins LF","Yao S","Kushi LH","Liu S","Kwan ML","Yang JJ","Yeh IT","Ergas IJ","Barlow WE","Larsen V","Albain KS","Hayes DF","Martino S","Zhu Q","Ambrosone CB","Kadlubar SA","Rae JM","Lyss AP"],"additional_accession":[]},"is_claimable":false,"name":"Germline Genetic Variants in GATA3 and Breast Cancer Treatment Outcomes in SWOG S8897 Trial and the Pathways Study.","description":"<h4>Introduction</h4>GATA3 is a critical transcription factor in maintaining the differentiated state of luminal mammary epithelial cells. We sought to determine the prognostic and predictive roles of GATA3 genotypes for breast cancer.<h4>Patients and methods</h4>Twelve single nucleotide polymorphisms (SNPs) were genotyped in 2 breast cancer cohorts, including the SWOG S8897 trial where patients were treated with adjuvant chemotherapy (CAF [cyclophosphamide, doxorubicin, 5-fluorouracil] vs. CMF [cyclophosphamide, methotrexate, 5-fluorouracil]) or untreated, and the observational Pathways Study.<h4>Results</h4>In the S8897 trial, rs3802604 and rs568727 were associated with disease-free survival and overall survival in the treated group, regardless of chemotherapy regimen. The GG genotype of","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2026-04-29T17:45:51.417Z","creation":"2020-09-11T07:22:16Z"},"accession":"S-EPMC6667288","cross_references":{"pubmed":["30928413"],"doi":["10.1016/j.clbc.2019.02.010"]}}