{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Raijmakers RP"],"funding":["Q-support Foundation"],"pagination":["ofz296"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6667718"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(7)"],"pubmed_abstract":["Although most patients recover from acute Q fever, around 20% develop Q fever fatigue syndrome (QFS), a debilitating fatigue syndrome that lasts at least 6 months. This study investigated transcriptional profiles of circulating monocytes and circulating cytokines as a subsequent mirror of myeloid cell function, 1 and 6 months after an acute Q fever infection. Total RNA of circulating monocytes was collected from 11 acute Q fever patients and 15 healthy controls, matched for age (±5 years) and sex. Samples were collected at a median of 27 days (baseline, interquartile range, 15-35 days) after the infection and again 6 months thereafter. Transcriptome analysis was performed using RNA sequencing. Additionally, concentrations of circulating interleukin (IL)-10, IL-1β, IL-1Ra, and IL-6 were mea"],"journal":["Open forum infectious diseases"],"pubmed_title":["Long-Lasting Transcriptional Changes in Circulating Monocytes of Acute Q Fever Patients."],"pmcid":["PMC6667718"],"funding_grant_id":["UMCN-160708-00"],"pubmed_authors":["Keijmel SP","Bleeker-Rovers CP","Nguyen C","Ter Horst R","Stenos J","Joosten LA","Van Der Meer JW","Novakovic B","Graves SR","Raijmakers RP","Netea MG"],"additional_accession":[]},"is_claimable":false,"name":"Long-Lasting Transcriptional Changes in Circulating Monocytes of Acute Q Fever Patients.","description":"Although most patients recover from acute Q fever, around 20% develop Q fever fatigue syndrome (QFS), a debilitating fatigue syndrome that lasts at least 6 months. This study investigated transcriptional profiles of circulating monocytes and circulating cytokines as a subsequent mirror of myeloid cell function, 1 and 6 months after an acute Q fever infection. Total RNA of circulating monocytes was collected from 11 acute Q fever patients and 15 healthy controls, matched for age (±5 years) and sex. Samples were collected at a median of 27 days (baseline, interquartile range, 15-35 days) after the infection and again 6 months thereafter. Transcriptome analysis was performed using RNA sequencing. Additionally, concentrations of circulating interleukin (IL)-10, IL-1β, IL-1Ra, and IL-6 were mea","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jul","modification":"2025-04-04T22:09:07.451Z","creation":"2019-08-09T07:04:10Z"},"accession":"S-EPMC6667718","cross_references":{"pubmed":["31363773"],"doi":["10.1093/ofid/ofz296"]}}