biostudies-literatureAke JAMilitary Infectious Disease Research ProgramNIMH NIH HHSPEPFARNational Institute of Mental Health639-647https://www.ebi.ac.uk/biostudies/studies/S-EPMC6669288biostudies-literatureUnknown69(4)<h4>Background</h4>Noninfectious comorbid diseases (NCDs) contribute to morbidity and mortality in human immunodeficiency virus (HIV)-infected populations in resource-rich countries. With antiretroviral therapy (ART) scale-up in Africa, understanding burden NCD informs public health strategy.<h4>Methods</h4>At enrollment, participants at 11 HIV clinics in Kenya, Uganda, Tanzania, and Nigeria underwent medical history, physical, laboratory, and neuropsychological assessments to identify elevated blood pressure, hypercholesterolemia, dysglycemia, renal insufficiency, and cognitive impairment. Poisson regression models estimated adjusted relative risks (ARRs) and 95% confidence intervals (CIs) for the number of NCDs associated with factors of interest. Logistic regression was used to evaluateClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaNoninfectious Comorbidity in the African Cohort Study.PMC6669288K24MH098759K24 MH098759W81XWH-11-2-0174Hamm TELangat EAgutu JLangat KKnopp GWangiri PKroidl IKiliba PAdegbite OAAyogu MTiamiyu ABKroidl ALangat RMkingule NMcharo RIkegbunam AUZhang CMfumbulwa HAfoke KChangwony EJjuuko SBirungi HDavid GKipkoech CAtwijuka BWilliams TTMabwai MElemere JOwuoth JRotich JRwomushana IRotich LMtafya BMbibi JCRono AOlomi WObambo KFalodun OSanagare ABor LSande NKafeero CHickey PWKesi ZChumba EMbena TWanjiru FAfrican Cohort Study TeamKapkiai JTonui COni FOOdeyemi SOLwilla AMwandumbya LDogonyaro BShehu MUkaegbu ICAdelakun GABii MGitonga DNdbuisi RONambuya AMwasulama OMebrahtu TKirui ROdo AFBagyendagye EMaganga LRehema WSing'oei VKiprotich SGanesan KKeshinro BNantabo MOdemba ESemwogerere MSsentongo FMichael NLChelangat EMbwayu FNicholas EIThompson CSugut JChepkwony PEller LAMilazzo MKiweewa FMaswai JUgwuezumba OChepkemoi WLikiliwike JMugagga OPolyak CSMalia JWangare SKibuuka HOchola JMkondoo DDaniel HLabosso KIyanda TImbach MNambulondo POkolo COtieno SHarrison NEMwesigwa RMangesoi REnameguono ONwando HParikh APOuma IOtieno LEluwa RMOkwaro CEsber ALValcour VGSomi NMwamwaja JTegamanyi JAgbaim UCMene VYAdimo OLiu MKisinda ANgetich RMwaisanga GMwaipopo MMaera ENabanoba CTSong KTindikahwa AOkeke NCLueer CGeldmacher CKorir JOgari CMaranga EKhamadi SCoakley PNamagembe REdwin PAke JALombardi KAzuakola NAkinseli OCrowell TASmith GKasembeli AUmeji LKishimbo PDeshano RPeel SNassali GMillard MAkintunde AChiweka ERose AAsiimwe AOlabulo OOgai SNyapiedho OMuhumuza JRobb MLNgeno JAdamu YBahemana EOnukun FfalseNoninfectious Comorbidity in the African Cohort Study.<h4>Background</h4>Noninfectious comorbid diseases (NCDs) contribute to morbidity and mortality in human immunodeficiency virus (HIV)-infected populations in resource-rich countries. With antiretroviral therapy (ART) scale-up in Africa, understanding burden NCD informs public health strategy.<h4>Methods</h4>At enrollment, participants at 11 HIV clinics in Kenya, Uganda, Tanzania, and Nigeria underwent medical history, physical, laboratory, and neuropsychological assessments to identify elevated blood pressure, hypercholesterolemia, dysglycemia, renal insufficiency, and cognitive impairment. Poisson regression models estimated adjusted relative risks (ARRs) and 95% confidence intervals (CIs) for the number of NCDs associated with factors of interest. Logistic regression was used to evaluate2019-01-01T00:00:00Z2019 Aug2025-04-19T13:50:52.091Z2020-05-21T19:29:19ZS-EPMC66692883047600110.1093/cid/ciy981