biostudies-literatureUnknown11(7)Adhab MIn this paper we have characterized the lineage of two traits associated with the coat proteins (CPs) of the tombusvirids: Silencing suppression and HR elicitation in <i>Nicotiana</i> species. We considered that the tombusvirid CPs might collectively be considered an effector, with the CP of each CP-encoding species comprising a structural variant within the family. Thus, a phylogenetic analysis of the CP could provide insight into the evolution of a pathogen effector. The phylogeny of the CP of tombusvirids indicated that CP representatives of the family could be divided into four clades. In two separate clades the CP triggered a hypersensitive response (HR) in <i>Nicotiana</i> species of section <i>Alatae</i> but did not have silencing suppressor activity. In a third clade the CP had a sVirusesE588https://www.ebi.ac.uk/biostudies/studies/S-EPMC6669612biostudies-literatureTracing the Lineage of Two Traits Associated with the Coat Protein of the <i>Tombusviridae</i>: Silencing Suppression and HR Elicitation in <i>Nicotiana</i> Species.PMC6669612Angel CFereidouni MAdhab MSchoelz JEScheets KRodriguez AKiraly LfalseTracing the Lineage of Two Traits Associated with the Coat Protein of the <i>Tombusviridae</i>: Silencing Suppression and HR Elicitation in <i>Nicotiana</i> Species.In this paper we have characterized the lineage of two traits associated with the coat proteins (CPs) of the tombusvirids: Silencing suppression and HR elicitation in <i>Nicotiana</i> species. We considered that the tombusvirid CPs might collectively be considered an effector, with the CP of each CP-encoding species comprising a structural variant within the family. Thus, a phylogenetic analysis of the CP could provide insight into the evolution of a pathogen effector. The phylogeny of the CP of tombusvirids indicated that CP representatives of the family could be divided into four clades. In two separate clades the CP triggered a hypersensitive response (HR) in <i>Nicotiana</i> species of section <i>Alatae</i> but did not have silencing suppressor activity. In a third clade the CP had a s2019-01-01T00:00:00Z2019 Jun2026-04-08T05:18:25.892Z2019-08-12T07:05:12ZS-EPMC66696123126165210.3390/v11070588