{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cahill LE"],"funding":["NHLBI NIH HHS","Foundation for the National Institutes of Health","NCI NIH HHS"],"pagination":["1457-1464"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6672045"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["60(8)"],"pubmed_abstract":["The capacity of HDLs to accept cholesterol effluxing from macrophages has been proposed as a new biomarker of HDLs' anti-atherogenic function. Whether cholesterol efflux capacity (CEC) is independent of HDL cholesterol (HDL-C) as a biomarker for coronary heart disease (CHD) risk in a generally healthy primary-prevention population remains unanswered. Therefore, in this nested case-control study, we simultaneously assessed CEC (using J774 cells) and plasma HDL-C levels as predictors of CHD in healthy middle-aged and older men not receiving treatment affecting blood lipid concentrations. We used risk-set sampling of participants free of disease at baseline from the Health Professionals Follow-Up Study, and matched cases (n = 701) to controls 1:1 for age, smoking, and blood sampling date. We applied conditional logistic regression models to calculate the multivariable relative risk and 95% CIs of CHD over 16 years of follow-up. CEC and HDL-C were correlated (<i>r</i> = 0.50, <i>P</i> < 0.0001). The risk (95% CI) of CHD per one SD higher CEC was 0.82 (0.71-0.96), but completely attenuated to 1.08 (0.85-1.37) with HDL-C in the model. The association per one SD between HDL-C and CHD (0.66; 0.58-0.76) was essentially unchanged (0.68; 0.53-0.88) after adjustment for CEC. These findings indicate that CEC's ability to predict CHD may not be independent of HDL-C in a cohort of generally healthy men."],"journal":["Journal of lipid research"],"pubmed_title":["Cholesterol efflux capacity, HDL cholesterol, and risk of coronary heart disease: a nested case-control study in men."],"pmcid":["PMC6672045"],"funding_grant_id":["R01 HL035464","R01 HL35464","UM1 CA167552"],"pubmed_authors":["Cahill LE","Rimm EB","Sacks FM","Jensen MK"],"additional_accession":[]},"is_claimable":false,"name":"Cholesterol efflux capacity, HDL cholesterol, and risk of coronary heart disease: a nested case-control study in men.","description":"The capacity of HDLs to accept cholesterol effluxing from macrophages has been proposed as a new biomarker of HDLs' anti-atherogenic function. Whether cholesterol efflux capacity (CEC) is independent of HDL cholesterol (HDL-C) as a biomarker for coronary heart disease (CHD) risk in a generally healthy primary-prevention population remains unanswered. Therefore, in this nested case-control study, we simultaneously assessed CEC (using J774 cells) and plasma HDL-C levels as predictors of CHD in healthy middle-aged and older men not receiving treatment affecting blood lipid concentrations. We used risk-set sampling of participants free of disease at baseline from the Health Professionals Follow-Up Study, and matched cases (n = 701) to controls 1:1 for age, smoking, and blood sampling date. We applied conditional logistic regression models to calculate the multivariable relative risk and 95% CIs of CHD over 16 years of follow-up. CEC and HDL-C were correlated (<i>r</i> = 0.50, <i>P</i> < 0.0001). The risk (95% CI) of CHD per one SD higher CEC was 0.82 (0.71-0.96), but completely attenuated to 1.08 (0.85-1.37) with HDL-C in the model. The association per one SD between HDL-C and CHD (0.66; 0.58-0.76) was essentially unchanged (0.68; 0.53-0.88) after adjustment for CEC. These findings indicate that CEC's ability to predict CHD may not be independent of HDL-C in a cohort of generally healthy men.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2025-04-29T10:31:29.934Z","creation":"2025-04-06T19:29:59.537Z"},"accession":"S-EPMC6672045","cross_references":{"pubmed":["31142574"],"doi":["10.1194/jlr.p093823","10.1194/jlr.P093823"]}}