biostudies-literatureShu XNational Natural Science Foundation of China577https://www.ebi.ac.uk/biostudies/studies/S-EPMC6675792biostudies-literatureUnknown10(8)Although multiple hypotheses had been proposed to clarify the causes of depression, the accurate pathogenesis and effective treatment of depression still need to be solved. Pathological change of astrocytes has been recognized to play a pivotal role in depression. Fluoxetine is the first selective serotonin reuptake inhibitor, however, the underlying mechanisms of fluoxetine are incompletely excavated. Emerging evidence shows that fluoxetine promotes autophagic processes in tumor cells. However, whether astrocytic autophagy gets involved in the cytoprotection of fluoxetine on astrocytes in depression treatment remains unexplored. Here we prepared chronic mild stress (CMS)-induced mouse model and treated mice with fluoxetine (10 mg/kg) for 4 weeks to determine the correlation between proautCell death & diseaseThe effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression.PMC667579281630099814731968157340381773706Lu MHu GBian YShu ZShu XSun XZhou YDing JSun YfalseThe effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression.Although multiple hypotheses had been proposed to clarify the causes of depression, the accurate pathogenesis and effective treatment of depression still need to be solved. Pathological change of astrocytes has been recognized to play a pivotal role in depression. Fluoxetine is the first selective serotonin reuptake inhibitor, however, the underlying mechanisms of fluoxetine are incompletely excavated. Emerging evidence shows that fluoxetine promotes autophagic processes in tumor cells. However, whether astrocytic autophagy gets involved in the cytoprotection of fluoxetine on astrocytes in depression treatment remains unexplored. Here we prepared chronic mild stress (CMS)-induced mouse model and treated mice with fluoxetine (10 mg/kg) for 4 weeks to determine the correlation between proaut2019-01-01T00:00:00Z2019 Aug2025-04-18T18:56:03.536Z2019-08-07T07:08:54ZS-EPMC66757923137171910.1038/s41419-019-1813-9