{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang JH"],"funding":["National Defense Medical Center","Cheng Hsin General Hospital","Ministry of Science and Technology, Taiwan, ROC","Taoyuan Armed Forces General Hospital"],"pagination":["300"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6683452"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["Background
A chronic inflammatory state is a prominent feature in patients with end-stage renal disease (ESRD). Nuclear factor-kappa B (NF-κB) is a transcription factor that regulates the expression of genes involved in inflammation. Some genetic studies have demonstrated that the NF-κB genetic mutation could cause kidney injury and kidney disease progression. However, the association of a gene polymorphism in the transcription factor binding site of NF-κB with kidney disease is not clear.Methods
We used the Taiwan Biobank database, the University of California, Santa Cruz, reference genome, and a chromatin immunoprecipitation sequencing database to find single nucleotide polymorphisms (SNPs) at potential binding sites of NF-κB. In addition, we performed a case-control stud"],"journal":["BMC nephrology"],"pubmed_title":["Investigation of the variants at the binding site of inflammatory transcription factor NF-κB in patients with end-stage renal disease."],"pmcid":["PMC6683452"],"funding_grant_id":["TAFGH-10429, TAFGH-10801","MAB-1050113, MAB-106-105, MAB-107-074, MAB-108-047","MOST107-2314-B016-052-MY3","CH-NDMC-105-5, CH-NDMC-106-4, CH-NDMC-107-13, CH-NDMC-108-6"],"pubmed_authors":["Hsu YJ","Lee MC","Chin-Lin","Fang WH","Chen CF","Kuo CW","Su SL","Yang JH","Chen WT","Lin YH","Chang HL","Chen HC","Hsiao PJ","Tu MY"],"additional_accession":[]},"is_claimable":false,"name":"Investigation of the variants at the binding site of inflammatory transcription factor NF-κB in patients with end-stage renal disease.","description":"Background
A chronic inflammatory state is a prominent feature in patients with end-stage renal disease (ESRD). Nuclear factor-kappa B (NF-κB) is a transcription factor that regulates the expression of genes involved in inflammation. Some genetic studies have demonstrated that the NF-κB genetic mutation could cause kidney injury and kidney disease progression. However, the association of a gene polymorphism in the transcription factor binding site of NF-κB with kidney disease is not clear.Methods
We used the Taiwan Biobank database, the University of California, Santa Cruz, reference genome, and a chromatin immunoprecipitation sequencing database to find single nucleotide polymorphisms (SNPs) at potential binding sites of NF-κB. In addition, we performed a case-control stud","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2026-05-01T04:42:05.566Z","creation":"2019-08-13T07:04:05Z"},"accession":"S-EPMC6683452","cross_references":{"pubmed":["31382928"],"doi":["10.1186/s12882-019-1471-2"]}}