biostudies-literatureYang JHNational Defense Medical CenterCheng Hsin General HospitalMinistry of Science and Technology, Taiwan, ROCTaoyuan Armed Forces General Hospital300https://www.ebi.ac.uk/biostudies/studies/S-EPMC6683452biostudies-literatureUnknown20(1)<h4>Background</h4>A chronic inflammatory state is a prominent feature in patients with end-stage renal disease (ESRD). Nuclear factor-kappa B (NF-κB) is a transcription factor that regulates the expression of genes involved in inflammation. Some genetic studies have demonstrated that the NF-κB genetic mutation could cause kidney injury and kidney disease progression. However, the association of a gene polymorphism in the transcription factor binding site of NF-κB with kidney disease is not clear.<h4>Methods</h4>We used the Taiwan Biobank database, the University of California, Santa Cruz, reference genome, and a chromatin immunoprecipitation sequencing database to find single nucleotide polymorphisms (SNPs) at potential binding sites of NF-κB. In addition, we performed a case-control studBMC nephrologyInvestigation of the variants at the binding site of inflammatory transcription factor NF-κB in patients with end-stage renal disease.PMC6683452TAFGH-10429, TAFGH-10801MAB-1050113, MAB-106-105, MAB-107-074, MAB-108-047MOST107-2314-B016-052-MY3CH-NDMC-105-5, CH-NDMC-106-4, CH-NDMC-107-13, CH-NDMC-108-6Hsu YJLee MCChin-LinFang WHChen CFKuo CWSu SLYang JHChen WTLin YHChang HLChen HCHsiao PJTu MYfalseInvestigation of the variants at the binding site of inflammatory transcription factor NF-κB in patients with end-stage renal disease.<h4>Background</h4>A chronic inflammatory state is a prominent feature in patients with end-stage renal disease (ESRD). Nuclear factor-kappa B (NF-κB) is a transcription factor that regulates the expression of genes involved in inflammation. Some genetic studies have demonstrated that the NF-κB genetic mutation could cause kidney injury and kidney disease progression. However, the association of a gene polymorphism in the transcription factor binding site of NF-κB with kidney disease is not clear.<h4>Methods</h4>We used the Taiwan Biobank database, the University of California, Santa Cruz, reference genome, and a chromatin immunoprecipitation sequencing database to find single nucleotide polymorphisms (SNPs) at potential binding sites of NF-κB. In addition, we performed a case-control stud2019-01-01T00:00:00Z2019 Aug2026-05-01T04:42:05.566Z2019-08-13T07:04:05ZS-EPMC66834523138292810.1186/s12882-019-1471-2