{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Holmberg D"],"funding":["Vetenskapsrådet","Cancerfonden"],"pagination":["2901-2908"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6684532"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(9)"],"pubmed_abstract":["<h4>Background</h4>Individuals with Barrett's esophagus (BE) are at increased risk of high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC), but the cost-effectiveness of general surveillance of BE is low. This study aimed to identify a risk prediction model for tumor progression in individuals with BE based on age, sex, and risk factors found at upper endoscopy, enabling tailored surveillance.<h4>Methods</h4>This nested case-control study originated from a cohort of 8171 adults diagnosed with BE in 2006-2013 in the Swedish Patient Registry. Cases had EAC/HGD (n = 279) as identified from the Swedish Cancer Registry, whereas controls had no EAC/HGD (n = 1089). Findings from endoscopy and histopathology reports were extracted from medical records at 71 Swedish hospitals and from the"],"journal":["Surgical endoscopy"],"pubmed_title":["Clinical prediction model for tumor progression in Barrett's esophagus."],"pmcid":["PMC6684532"],"funding_grant_id":["CAN 2015/460","E0253601","D0547801"],"pubmed_authors":["Lagergren J","Holmberg D","Ness-Jensen E","Mattsson F"],"additional_accession":[]},"is_claimable":false,"name":"Clinical prediction model for tumor progression in Barrett's esophagus.","description":"<h4>Background</h4>Individuals with Barrett's esophagus (BE) are at increased risk of high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC), but the cost-effectiveness of general surveillance of BE is low. This study aimed to identify a risk prediction model for tumor progression in individuals with BE based on age, sex, and risk factors found at upper endoscopy, enabling tailored surveillance.<h4>Methods</h4>This nested case-control study originated from a cohort of 8171 adults diagnosed with BE in 2006-2013 in the Swedish Patient Registry. Cases had EAC/HGD (n = 279) as identified from the Swedish Cancer Registry, whereas controls had no EAC/HGD (n = 1089). Findings from endoscopy and histopathology reports were extracted from medical records at 71 Swedish hospitals and from the","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2025-04-05T10:42:50.185Z","creation":"2019-08-28T07:02:34Z"},"accession":"S-EPMC6684532","cross_references":{"pubmed":["30456503"],"doi":["10.1007/s00464-018-6590-5"]}}