{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Szel E"],"pubmed_abstract":["To better understand the pathomechanism of psoriasis, a comparative proteomic analysis was performed with non-lesional and lesional skin from psoriasis patients and skin from healthy individuals. Strikingly, 79.9% of the proteins that were differentially expressed in lesional and healthy skin exhibited expression levels in non-lesional skin that were within twofold of the levels observed in healthy and lesional skin, suggesting that non-lesional skin represents an intermediate stage. Proteins outside this trend were categorized into three groups: I. proteins in non-lesional skin exhibiting expression similar to lesional skin, which might be predisposing factors (i.e., CSE1L, GART, MYO18A and UGDH); II. proteins that were differentially expressed in non-lesional and lesional skin but not in"],"journal":["Scientific reports"],"pagination":["11382"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6684579"],"repository":["biostudies-literature"],"pubmed_title":["Comprehensive Proteomic Analysis Reveals Intermediate Stage of Non-Lesional Psoriatic Skin and Points out the Importance of Proteins Outside this Trend."],"pmcid":["PMC6684579"],"pubmed_authors":["Bozo R","Hunyadi-Gulyas E","Manczinger M","Kemeny L","Bata-Csorgo Z","Szel E","Szabo K","Groma G"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive Proteomic Analysis Reveals Intermediate Stage of Non-Lesional Psoriatic Skin and Points out the Importance of Proteins Outside this Trend.","description":"To better understand the pathomechanism of psoriasis, a comparative proteomic analysis was performed with non-lesional and lesional skin from psoriasis patients and skin from healthy individuals. Strikingly, 79.9% of the proteins that were differentially expressed in lesional and healthy skin exhibited expression levels in non-lesional skin that were within twofold of the levels observed in healthy and lesional skin, suggesting that non-lesional skin represents an intermediate stage. Proteins outside this trend were categorized into three groups: I. proteins in non-lesional skin exhibiting expression similar to lesional skin, which might be predisposing factors (i.e., CSE1L, GART, MYO18A and UGDH); II. proteins that were differentially expressed in non-lesional and lesional skin but not in","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2026-04-29T15:16:00.429Z","creation":"2026-04-07T15:21:01.27Z"},"accession":"S-EPMC6684579","cross_references":{"pubmed":["31388062"],"doi":["10.1038/s41598-019-47774-5"]}}