{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":89,"searchCount":0},"additional":{"submitter":["Chen ZM"],"funding":["National Institute of General Medical Sciences"],"pagination":["7246-7250"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6685350"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(30)"],"pubmed_abstract":["A regioselective and enantioselective palladium-catalyzed relay Heck alkenylation of alkenylbenzene derivatives to construct remote stereocenters is disclosed. Various β-substituted styrenes were readily obtained in moderate yields with good to excellent levels of enantioselectivity. This strategy provides rapid access to enantioenriched δ, ε, ζ, and η-alkenyl aryl compounds from simple starting materials. Mechanistic studies suggest that termination of the relay reaction is controlled by affinity of the arene for the Pd complex during migration."],"journal":["Chemical science"],"pubmed_title":["Palladium-catalyzed enantioselective alkenylation of alkenylbenzene derivatives."],"pmcid":["PMC6685350"],"funding_grant_id":["NIGMS R01GM063540"],"pubmed_authors":["Liu J","DeLuca RJ","Guo JY","Sigman MS","Chen ZM","Loch M"],"view_count":["89"],"additional_accession":[]},"is_claimable":false,"name":"Palladium-catalyzed enantioselective alkenylation of alkenylbenzene derivatives.","description":"A regioselective and enantioselective palladium-catalyzed relay Heck alkenylation of alkenylbenzene derivatives to construct remote stereocenters is disclosed. Various β-substituted styrenes were readily obtained in moderate yields with good to excellent levels of enantioselectivity. This strategy provides rapid access to enantioenriched δ, ε, ζ, and η-alkenyl aryl compounds from simple starting materials. Mechanistic studies suggest that termination of the relay reaction is controlled by affinity of the arene for the Pd complex during migration.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2024-02-14T20:06:49.209Z","creation":"2019-10-11T07:03:01Z"},"accession":"S-EPMC6685350","cross_references":{"pubmed":["31588293"],"doi":["10.1039/c9sc02380a"]}}