biostudies-literatureMao XNIA NIH HHSNIDDK NIH HHSKaiser Foundation Research InstituteNHLBI NIH HHSNational Heart, Lung, and Blood InstituteUniversity of MinnesotaNorthwestern UniversityUniversity of AlabamaNational Institutes of HealthJohns Hopkins University School of MedicineNational Institute on Aging1424-1433https://www.ebi.ac.uk/biostudies/studies/S-EPMC6686058biostudies-literatureUnknown149(8)<h4>Background</h4>Vegetables and fruits (VF) may differentially affect cognitive functions, presumably due to their various nutrient contents, but evidence from epidemiologic studies is limited.<h4>Objectives</h4>The aim of this study was to examine the long-term association between VF intakes, including VF subgroups, in young adulthood and cognitive function in midlife.<h4>Methods</h4>A biracial cohort of 3231 men and women aged 18-30 y at baseline in 1985-1986 were followed up for 25 y in the Coronary Artery Risk Development in Young Adults Study. Diet was measured at baseline, and in examination years 7 and 20. Cognitive function was assessed at examination year 25 through the use of 3 tests: the Rey Auditory Verbal Learning Test (RAVLT), the Digit Symbol Substitution Test (DSST), and The Journal of nutritionIntake of Vegetables and Fruits Through Young Adulthood Is Associated with Better Cognitive Function in Midlife in the US General Population.PMC6686058HHSN268200900041CAG0005R01DK116603R01 AG045611HHSN268201300028CHHSN268201300027CR01 DK116603HHSN268201300029CR01AG056111HHSN268201300026CHHSN268201300025CDaviglus MLSteffen LMZhu NSidney SMao XHe KChen CJacobs DRVan Horn LQin BXun PfalseIntake of Vegetables and Fruits Through Young Adulthood Is Associated with Better Cognitive Function in Midlife in the US General Population.<h4>Background</h4>Vegetables and fruits (VF) may differentially affect cognitive functions, presumably due to their various nutrient contents, but evidence from epidemiologic studies is limited.<h4>Objectives</h4>The aim of this study was to examine the long-term association between VF intakes, including VF subgroups, in young adulthood and cognitive function in midlife.<h4>Methods</h4>A biracial cohort of 3231 men and women aged 18-30 y at baseline in 1985-1986 were followed up for 25 y in the Coronary Artery Risk Development in Young Adults Study. Diet was measured at baseline, and in examination years 7 and 20. Cognitive function was assessed at examination year 25 through the use of 3 tests: the Rey Auditory Verbal Learning Test (RAVLT), the Digit Symbol Substitution Test (DSST), and 2019-01-01T00:00:00Z2019 Aug2025-04-29T10:31:17.494Z2025-04-06T19:33:19.775ZS-EPMC66860583116258610.1093/jn/nxz076