{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Fernandez-Calleja JMS"],"pubmed_abstract":["Indirect calorimetry (InCa) estimates whole-body energy expenditure and total substrate oxidation based on O<sub>2</sub> consumption and CO<sub>2</sub> production, but does not allow for the quantification of oxidation of exogenous substrates with time. To achieve this, we incorporated <sup>13</sup>CO<sub>2</sub> and <sup>12</sup>CO<sub>2</sub> gas sensors into a commercial InCa system and aimed to demonstrate their performance and added value. As a performance indicator, we showed the discriminative oscillations in <sup>13</sup>CO<sub>2</sub> enrichment associated with food intake in mice fed diets containing naturally low (wheat) vs high (maize) <sup>13</sup>C enrichment. To demonstrate the physiological value, we quantified exogenous vs total carbohydrate and fat oxidation continuously,"],"journal":["Scientific reports"],"pagination":["11507"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6687832"],"repository":["biostudies-literature"],"pubmed_title":["Extended indirect calorimetry with isotopic CO<sub>2</sub> sensors for prolonged and continuous quantification of exogenous vs. total substrate oxidation in mice."],"pmcid":["PMC6687832"],"pubmed_authors":["Swarts HJM","Fernandez-Calleja JMS","Bouwman LMS","Oosting A","Keijer J","van Schothorst EM"],"additional_accession":[]},"is_claimable":false,"name":"Extended indirect calorimetry with isotopic CO<sub>2</sub> sensors for prolonged and continuous quantification of exogenous vs. total substrate oxidation in mice.","description":"Indirect calorimetry (InCa) estimates whole-body energy expenditure and total substrate oxidation based on O<sub>2</sub> consumption and CO<sub>2</sub> production, but does not allow for the quantification of oxidation of exogenous substrates with time. To achieve this, we incorporated <sup>13</sup>CO<sub>2</sub> and <sup>12</sup>CO<sub>2</sub> gas sensors into a commercial InCa system and aimed to demonstrate their performance and added value. As a performance indicator, we showed the discriminative oscillations in <sup>13</sup>CO<sub>2</sub> enrichment associated with food intake in mice fed diets containing naturally low (wheat) vs high (maize) <sup>13</sup>C enrichment. To demonstrate the physiological value, we quantified exogenous vs total carbohydrate and fat oxidation continuously,","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2025-05-29T22:10:25.353Z","creation":"2025-05-29T22:10:25.353Z"},"accession":"S-EPMC6687832","cross_references":{"pubmed":["31395916"],"doi":["10.1038/s41598-019-47977-w"]}}