biostudies-literatureUnknown10Kao WTObjects: The aim of our study was to investigate whether major depressive disorder (MDD) increased the risk of hypertension using propensity score matching (PSM) in patients with MDD in Taiwan. Methods: In this study, we recruited all samples from a random sample sub-dataset of one million insured individuals from 2005. A total of 743,114 outpatients were included in our study. We used PSM (nearest neighbor matching) stratified by age, hospital level, insurance amount, and Charlson Comorbidity Index score. Results: The hazard ratio (HR) of hypertension was significantly greater in the male MDD outpatients (HR = 1.116, P = 0.004) than in the female MDD outpatients (HR = 0.93, P = 0.02). Using PSM, we selected 27,988 outpatients with hypertension and 27,988Frontiers in psychiatry541https://www.ebi.ac.uk/biostudies/studies/S-EPMC6688710biostudies-literatureGender Disparity in the Risk of Hypertension in Subjects With Major Depressive Disorder.PMC6688710Kao WTLung FWLin SLWu SLChang CLLin CHfalseGender Disparity in the Risk of Hypertension in Subjects With Major Depressive Disorder.Objects: The aim of our study was to investigate whether major depressive disorder (MDD) increased the risk of hypertension using propensity score matching (PSM) in patients with MDD in Taiwan. Methods: In this study, we recruited all samples from a random sample sub-dataset of one million insured individuals from 2005. A total of 743,114 outpatients were included in our study. We used PSM (nearest neighbor matching) stratified by age, hospital level, insurance amount, and Charlson Comorbidity Index score. Results: The hazard ratio (HR) of hypertension was significantly greater in the male MDD outpatients (HR = 1.116, P = 0.004) than in the female MDD outpatients (HR = 0.93, P = 0.02). Using PSM, we selected 27,988 outpatients with hypertension and 27,9882019-01-01T00:00:00Z20192025-05-29T21:07:08.537Z2025-05-29T21:07:08.537ZS-EPMC66887103142799910.3389/fpsyt.2019.00541