biostudies-literatureKim SYNational Research Foundation of Korea116https://www.ebi.ac.uk/biostudies/studies/S-EPMC6689875biostudies-literatureUnknown11(1)<h4>Background</h4>Oral squamous cell carcinoma (OSCC) is a genetic and epigenetic disease. There is growing evidence to suggest that environmental factors due to epigenetic changes can be involved in the OSCC pathogenesis. Although tumor suppressor genes (TSGs) are commonly inactivated by promoter hypermethylation in human cancers, the epigenetic changes and the mechanism of TSGs in human OSCC remain unclear. We therefore assessed the methylation status of the TSGs, which are associated with epigenetic silencing in human cancers, OSCC cell lines, primary tumors, and normal oral mucosa.<h4>Results</h4>We used 14 TSGs that were originally identified in colon cancer to investigate the aberrant hypermethylation of these genes associated with transcriptional silencing in 10 OSCC cell lines. WeClinical epigeneticsAberrantly hypermethylated tumor suppressor genes were identified in oral squamous cell carcinoma (OSCC).PMC6689875NRF-2018R1A5A2023879, NRF-2017R1A2B4005588Park HRKim SYSong JMLee CHYi JMHan YKKang KfalseAberrantly hypermethylated tumor suppressor genes were identified in oral squamous cell carcinoma (OSCC).<h4>Background</h4>Oral squamous cell carcinoma (OSCC) is a genetic and epigenetic disease. There is growing evidence to suggest that environmental factors due to epigenetic changes can be involved in the OSCC pathogenesis. Although tumor suppressor genes (TSGs) are commonly inactivated by promoter hypermethylation in human cancers, the epigenetic changes and the mechanism of TSGs in human OSCC remain unclear. We therefore assessed the methylation status of the TSGs, which are associated with epigenetic silencing in human cancers, OSCC cell lines, primary tumors, and normal oral mucosa.<h4>Results</h4>We used 14 TSGs that were originally identified in colon cancer to investigate the aberrant hypermethylation of these genes associated with transcriptional silencing in 10 OSCC cell lines. We2019-01-01T00:00:00Z2019 Aug2025-04-05T00:13:25.6Z2019-08-20T07:04:38ZS-EPMC66898753140537910.1186/s13148-019-0715-0