biostudies-literatureYang WDeutsche Forschungsgemeinschaft1793https://www.ebi.ac.uk/biostudies/studies/S-EPMC6693516biostudies-literatureUnknown10The biology of all organisms is influenced by the associated community of microorganisms. In spite of its importance, it is usually not well understood how exactly this microbiota affects host functions and what are the underlying molecular processes. To rectify this knowledge gap, we took advantage of the nematode <i>Caenorhabditis elegans</i> as a tractable, experimental model system and assessed the inducible transcriptome response after colonization with members of its native microbiota. For this study, we focused on two isolates of the genus <i>Ochrobactrum</i>. These bacteria are known to be abundant in the nematode's microbiota and are capable of colonizing and persisting in the nematode gut, even under stressful conditions. The transcriptome response was assessed across developmentFrontiers in microbiologyThe Inducible Response of the Nematode <i>Caenorhabditis elegans</i> to Members of Its Natural Microbiota Across Development and Adult Life.PMC6693516CRC 1182 project A1, INF, Z3EXC 2167-390884018Tholey AYang WSchulenburg HRosenstiel PDierking KPees BWaschina SDirksen PLeippe MKaleta CZimmermann JPetersen CfalseThe Inducible Response of the Nematode <i>Caenorhabditis elegans</i> to Members of Its Natural Microbiota Across Development and Adult Life.The biology of all organisms is influenced by the associated community of microorganisms. In spite of its importance, it is usually not well understood how exactly this microbiota affects host functions and what are the underlying molecular processes. To rectify this knowledge gap, we took advantage of the nematode <i>Caenorhabditis elegans</i> as a tractable, experimental model system and assessed the inducible transcriptome response after colonization with members of its native microbiota. For this study, we focused on two isolates of the genus <i>Ochrobactrum</i>. These bacteria are known to be abundant in the nematode's microbiota and are capable of colonizing and persisting in the nematode gut, even under stressful conditions. The transcriptome response was assessed across development2019-01-01T00:00:00Z20192026-04-08T05:44:55.049Z2019-08-26T07:02:34ZS-EPMC66935163144022110.3389/fmicb.2019.01793