{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lei YM"],"funding":["NIAID"],"pagination":["127569"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6693824"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5"],"pubmed_abstract":["Solid organ transplantation can treat end-stage organ failure, but the half-life of transplanted organs colonized with commensals is much shorter than that of sterile organs. Whether organ colonization plays a role in this shorter half-life is not known. We have previously shown that an intact whole-body microbiota can accelerate the kinetics of solid organ allograft rejection in untreated colonized mice when compared to germ-free (GF) or to antibiotic-pre-treated colonized mice, by enhancing the capacity of antigen presenting cells (APCs) to activate graft-reactive T cells. However, the contribution of intestinal versus skin microbiota to these effects was unknown. Here, we demonstrate that colonizing the skin of GF mice with a single commensal, Staphylococcus epidermidis (S. epi), while "],"journal":["JCI insight"],"pubmed_title":["Skin-restricted commensal colonization accelerates skin graft rejection."],"pmcid":["PMC6693824"],"funding_grant_id":["R01AI115716"],"pubmed_authors":["Chong AS","Alegre ML","Chen L","Theriault B","Belkaid Y","Sepulveda M","Lei YM","Wang Y","Pirozzolo I"],"additional_accession":[]},"is_claimable":false,"name":"Skin-restricted commensal colonization accelerates skin graft rejection.","description":"Solid organ transplantation can treat end-stage organ failure, but the half-life of transplanted organs colonized with commensals is much shorter than that of sterile organs. Whether organ colonization plays a role in this shorter half-life is not known. We have previously shown that an intact whole-body microbiota can accelerate the kinetics of solid organ allograft rejection in untreated colonized mice when compared to germ-free (GF) or to antibiotic-pre-treated colonized mice, by enhancing the capacity of antigen presenting cells (APCs) to activate graft-reactive T cells. However, the contribution of intestinal versus skin microbiota to these effects was unknown. Here, we demonstrate that colonizing the skin of GF mice with a single commensal, Staphylococcus epidermidis (S. epi), while ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jul","modification":"2025-04-04T19:04:54.155Z","creation":"2019-08-26T07:02:35Z"},"accession":"S-EPMC6693824","cross_references":{"pubmed":["31310590"],"doi":["10.1172/jci.insight.127569"]}}