{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["197(3)"],"submitter":["Peters FS"],"pubmed_abstract":["Cutaneous squamous cell carcinoma (cSCC) is a serious complication after organ transplantation and patients benefit from an early risk assessment. We hypothesized that functional differences in circulating T cells may represent risk factors for post-transplant cSCC development. Here, we analysed genome-wide DNA methylation of circulating T cells of kidney transplant recipients before the clinical onset of cSCC, to identify differences associated with post-transplant cSCC development. This analysis identified higher DNA methylation of SERPINB9, which is an intracellular inhibitor of granzyme B, a protein that induces apoptosis in target cells. High DNA methylation of SERPINB9 in circulating T cells was confirmed in a second patient cohort during recurrent cSCC, indicating that high SERPINB9"],"journal":["Clinical and experimental immunology"],"pagination":["341-351"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6693965"],"repository":["biostudies-literature"],"pubmed_title":["Disrupted regulation of serpinB9 in circulating T cells is associated with an increased risk for post-transplant skin cancer."],"pmcid":["PMC6693965"],"pubmed_authors":["Peters FS","Mooyaart AL","van de Wetering J","van den Bosch TPP","Peeters AMA","Betjes MGH","Baan CC","Boer K"],"additional_accession":[]},"is_claimable":false,"name":"Disrupted regulation of serpinB9 in circulating T cells is associated with an increased risk for post-transplant skin cancer.","description":"Cutaneous squamous cell carcinoma (cSCC) is a serious complication after organ transplantation and patients benefit from an early risk assessment. We hypothesized that functional differences in circulating T cells may represent risk factors for post-transplant cSCC development. Here, we analysed genome-wide DNA methylation of circulating T cells of kidney transplant recipients before the clinical onset of cSCC, to identify differences associated with post-transplant cSCC development. This analysis identified higher DNA methylation of SERPINB9, which is an intracellular inhibitor of granzyme B, a protein that induces apoptosis in target cells. High DNA methylation of SERPINB9 in circulating T cells was confirmed in a second patient cohort during recurrent cSCC, indicating that high SERPINB9","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2026-05-07T18:07:48.622Z","creation":"2019-08-23T07:04:51Z"},"accession":"S-EPMC6693965","cross_references":{"pubmed":["31059128"],"doi":["10.1111/cei.13309"]}}