{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["National Basic Research Program of China (973 Program)"],"pagination":["208"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6694441"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["Mild cognitive impairment (MCI) is a transitional state between the cognitive changes in normal aging and Alzheimer's disease (AD), which induces abnormalities in specific brain regions. Previous studies showed that paired helical filaments Tau (PHF-Tau) protein is a potential pathogenic protein which may cause abnormal brain function and structure in MCI and AD patients. However, the understanding of the PHF-Tau protein network in MCI patients is limited. In this study, 225 subjects with PHF-Tau Positron Emission Tomography (PET) images were divided into four groups based on whether they carried Apolipoprotein E ε4 (APOE 4) or abnormal cerebrospinal fluid Total-Tau (CSF T-Tau). They are two important pathogenic factors that might cause cognitive function impairment. The four groups were: "],"journal":["Frontiers in aging neuroscience"],"pubmed_title":["The Influence of Cerebrospinal Fluid Abnormalities and APOE 4 on PHF-Tau Protein: Evidence From Voxel Analysis and Graph Theory."],"pmcid":["PMC6694441"],"funding_grant_id":["2014CB744600"],"pubmed_authors":["Massoglia D","Crawford K","Carmichael O","Belden CM","Taylor JL","Grossman H","Stark S","Brewer J","Rosen HJ","James O","Pierce A","Lane B","Carrillo M","Chertkow H","Hart D","DeCarli C","Gunter J","Figurski M","Lord JL","Bonakdarpour B","Rogalski E","Montine T","Villanueva-Meyer J","Taylor-Reinwald L","Petrella JR","Mathis C","Rachinsky I","Woo E","Frank R","Oyonumo NE","Reyes D","Creech ML","Geldmacher D","Duara R","Hu B","Reeder S","Grafman J","Pasternack S","Oates E","Celmins D","Wu CK","Singleton-Garvin J","Pawluczyk S","Fletcher E","Lah JJ","Lin M","Bickford D","Raichle M","Munic D","Salloway S","Peskind ER","Vaishnavi S","Karlawish JH","Mintun MA","Turner RS","Capote H","Neu S","Feldman 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Evidence From Voxel Analysis and Graph Theory.","description":"Mild cognitive impairment (MCI) is a transitional state between the cognitive changes in normal aging and Alzheimer's disease (AD), which induces abnormalities in specific brain regions. Previous studies showed that paired helical filaments Tau (PHF-Tau) protein is a potential pathogenic protein which may cause abnormal brain function and structure in MCI and AD patients. However, the understanding of the PHF-Tau protein network in MCI patients is limited. In this study, 225 subjects with PHF-Tau Positron Emission Tomography (PET) images were divided into four groups based on whether they carried Apolipoprotein E ε4 (APOE 4) or abnormal cerebrospinal fluid Total-Tau (CSF T-Tau). They are two important pathogenic factors that might cause cognitive function impairment. The four groups were: ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-04T21:39:51.062Z","creation":"2019-08-26T07:02:42Z"},"accession":"S-EPMC6694441","cross_references":{"pubmed":["31440157"],"doi":["10.3389/fnagi.2019.00208"]}}