biostudies-literatureLi YNational Basic Research Program of China (973 Program)208https://www.ebi.ac.uk/biostudies/studies/S-EPMC6694441biostudies-literatureUnknown11Mild cognitive impairment (MCI) is a transitional state between the cognitive changes in normal aging and Alzheimer's disease (AD), which induces abnormalities in specific brain regions. Previous studies showed that paired helical filaments Tau (PHF-Tau) protein is a potential pathogenic protein which may cause abnormal brain function and structure in MCI and AD patients. However, the understanding of the PHF-Tau protein network in MCI patients is limited. In this study, 225 subjects with PHF-Tau Positron Emission Tomography (PET) images were divided into four groups based on whether they carried Apolipoprotein E ε4 (APOE 4) or abnormal cerebrospinal fluid Total-Tau (CSF T-Tau). They are two important pathogenic factors that might cause cognitive function impairment. The four groups were: Frontiers in aging neuroscienceThe Influence of Cerebrospinal Fluid Abnormalities and APOE 4 on PHF-Tau Protein: Evidence From Voxel Analysis and Graph Theory.PMC66944412014CB744600Massoglia DCrawford KCarmichael OBelden CMTaylor JLGrossman HStark SBrewer JRosen HJJames OPierce ALane BCarrillo MChertkow HHart DDeCarli CGunter JFigurski MLord JLBonakdarpour BRogalski EMontine TVillanueva-Meyer JTaylor-Reinwald LPetrella JRMathis CRachinsky IWoo EFrank ROyonumo NEReyes DCreech MLGeldmacher DDuara RHu BReeder SGrafman JPasternack SOates ECelmins DWu CKSingleton-Garvin JPawluczyk SFletcher ELah JJLin MBickford DRaichle MMunic DSalloway SPeskind ERVaishnavi SKarlawish JHMintun MATurner RSCapote HNeu SFeldman HKhachaturian ZJones DDang MKhouli REJohnson KALee TYMartin KSButters MDoraiswamy PMBernick CPreda AAsthana SWeintraub SYu YAisen PHosein COtt BRUlysse ABurns JMBecerra MHoltzman DBrockington JQuinn JSmith CDMintzer JSnyder PZmuda MHsiao JWinkfield DSwerdlow RHTremont GPaul SBorowski BHynes MLFargher KLandau SKoeppe RABrosch JRVaron DGoldstein BBorges-Neto SSorensen GJicha GCarter RReynolds BKowall NGreen RCSosa EReiman EMLove MNFinley SBurke ALi GChen KBrand CSilverman DHRavdin LPetrie ECNelson CBell KLTeodoro LSirrel SACarlsson CMJacobson SAZimmerman EAPomara NHergesheimer LLamb ALi YFleisher AClark CMTeng ESadowsky CFriedl KNho KPorsteinsson APSadowski MTingus KMiller BLJohnson KHsiung GRFranklin EKaye JAJohnson NPavlik VPoki-Walker KHayes JSchuff NJohnson SSheikh MOMartinez WKertesz AZou YKass JSHonig LSShah RCLerner AMorris JFillit HKerwin DSchultz SKChao SLind BVillena TBachman DJagust WSaykin AJMason SSOng EFaber KMMintz AHeidebrink JLRosen HGessert DRosen AScharre DWPavlosky WAlbert MAnderson KNam KWFaber KApostolova LPotkin SGThompson PSamuels PAlbers CSYeh RKittur SVemuri PFinger EPetersen RShen LOliver ALeach CBudson AEClark DWolk DATinklenberg JSenjem MOnyike CFox NYanez BVanderswag HIsmail MSHarless KThal LMartin KFurst AJSalazar JVarma PFleischman DShaffer ESpann BMStern YBartzokis GGreig MTScherer KFatica PHefti FColeman EBartha RMitsis EDeMarco KNorbash ATatsuoka CDavies PConrad GWalter SKielb SCatalinotto DZiolkowski JKnopman DOgunlana OMaillard PMiller DDBernstein MKilliany RYesavage JATarawneh RNeylan TKataki MCairns NJQuiceno MDrost DOakley MArfanakis KFu YBuckholtz NToga AWKoleva HLee AChiang GJohnson SCCabrera YD'Agostino DSantulli RBSabbagh MNIsland RFlashman LAHake AMBehan KForoud TMYesavage JSchneider SPacini NGaikwad MFernandez DWeiner MSnyder PJSarrael ABlank KRaman RKim SRelkin NArnold SESperling RACarson RELee VHouseholder EBrooks WMBlack SRainka MSmith KEPearlson GDFarlow MRMudge BBeckett LCarroll MJack CRHerring SLopez OLMesulam MMKremen SLipowski KGraff-Radford NRDolen SGreig-Custo MTWolday SFoster NKeltz MOgrocki PAu YHvan Dyck CHSossi VLamar MHernando RStefanovic BHergesheimen LMalloy PHetelle JYang MGriffith RBates VLu PHKowalksi NMarson DWong TZWeiner MWPotter WZamrini ESimpson DMHeyn CCKorecka MKuller LHarvey DShibley VWard CCorreia SFruehling JJWomack KBrawman-Mintzer OHardy PMathews DMatthews BRAnces BDrake EShim HDoody RSChowdhury MAlzheimer’s Disease Neuroimaging InitiativeMackin SYao ZWitbracht MNudelman KNPotkin SBorrie MBergman HOlichney JTrncic NDeCArli CSeltzer MRogers JThai GHarding SRodriguez RMakino KMPerry DCellar JSMarshall GASchneider LSSpicer KLevey AIObisesan TOPasternak SSmith ATrojanowki JQSilbert LCMarshall GParfitt FDonohue MMorris JCDaiello LABodge CJohnson PLRaj BAJimenez GRountree SNguyen DAllard JAssaly MTariot PGoldstein BSShaw LMSink KMKantarci KfalseThe Influence of Cerebrospinal Fluid Abnormalities and APOE 4 on PHF-Tau Protein: Evidence From Voxel Analysis and Graph Theory.Mild cognitive impairment (MCI) is a transitional state between the cognitive changes in normal aging and Alzheimer's disease (AD), which induces abnormalities in specific brain regions. Previous studies showed that paired helical filaments Tau (PHF-Tau) protein is a potential pathogenic protein which may cause abnormal brain function and structure in MCI and AD patients. However, the understanding of the PHF-Tau protein network in MCI patients is limited. In this study, 225 subjects with PHF-Tau Positron Emission Tomography (PET) images were divided into four groups based on whether they carried Apolipoprotein E ε4 (APOE 4) or abnormal cerebrospinal fluid Total-Tau (CSF T-Tau). They are two important pathogenic factors that might cause cognitive function impairment. The four groups were: 2019-01-01T00:00:00Z20192025-04-04T21:39:51.062Z2019-08-26T07:02:42ZS-EPMC66944413144015710.3389/fnagi.2019.00208