{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Trickey A"],"funding":["National Institute of Health-funded programme","NIDA NIH HHS","NIAID NIH HHS","NHMRC research fellowships","National Institute on Drug Abuse"],"pagination":["435-444"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6698583"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(6)"],"pubmed_abstract":["<h4>Background</h4>WHO aims to eliminate the hepatitis C virus (HCV) as a public health threat by 2030. Injection drug use is an important risk factor for HCV transmission, but its contribution to country-level and global epidemics is unknown. We estimated the contribution of injection drug use to risk for HCV epidemics globally, regionally, and at country level.<h4>Methods</h4>We developed a dynamic deterministic HCV transmission model to simulate country-level HCV epidemics among people who inject drugs and the general population. Each country's model was calibrated using country-specific data from UN datasets and systematic reviews on the prevalence of HCV and injection drug use. The population attributable fraction of HCV transmission associated with injection drug use was estimated-de"],"journal":["The lancet. Gastroenterology & hepatology"],"pubmed_title":["The contribution of injection drug use to hepatitis C virus transmission globally, regionally, and at country level: a modelling study."],"pmcid":["PMC6698583"],"funding_grant_id":["R01 DA037773","R01 DA044170","GNT1135991","GNT1041742","P30 AI036214","GNT1140938","GNT1091878","R01 DA1104470"],"pubmed_authors":["Trickey A","Larney S","Grebely J","Leung J","Walker JG","Fraser H","Peacock A","May MT","Vickerman P","Colledge S","Martin NK","Hickman M","Degenhardt L","Lim AG"],"additional_accession":[]},"is_claimable":false,"name":"The contribution of injection drug use to hepatitis C virus transmission globally, regionally, and at country level: a modelling study.","description":"<h4>Background</h4>WHO aims to eliminate the hepatitis C virus (HCV) as a public health threat by 2030. Injection drug use is an important risk factor for HCV transmission, but its contribution to country-level and global epidemics is unknown. We estimated the contribution of injection drug use to risk for HCV epidemics globally, regionally, and at country level.<h4>Methods</h4>We developed a dynamic deterministic HCV transmission model to simulate country-level HCV epidemics among people who inject drugs and the general population. Each country's model was calibrated using country-specific data from UN datasets and systematic reviews on the prevalence of HCV and injection drug use. The population attributable fraction of HCV transmission associated with injection drug use was estimated-de","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2025-06-01T00:53:38.636Z","creation":"2025-06-01T00:53:38.636Z"},"accession":"S-EPMC6698583","cross_references":{"pubmed":["30981685"],"doi":["10.1016/S2468-1253(19)30085-8","10.1016/s2468-1253(19)30085-8"]}}