{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Horsburgh K"],"funding":["British Heart Foundation","National Centre for the Replacement, Refinement and Reduction of Animals in Research","NIA NIH HHS","Department of Health","Lundbeck Foundation","Academy of Medical Sciences","Stroke Association","Rosetrees Trust","Epilepsy Research UK","Alzheimers Research UK","Medical Research Council","Chief Scientist Office","NINDS NIH HHS","Novo Nordisk Fonden"],"pagination":["851-868"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6700732"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["132(8)"],"pubmed_abstract":["Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized."],"journal":["Clinical science (London, England : 1979)"],"pubmed_title":["Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology."],"pmcid":["PMC6700732"],"funding_grant_id":["NNF13OC0004258","TSA2008/09","UKDRI-4002","MR/R005567/1","ART-PG2010-3","MR/N003403/1","P1501","UKDRI-4005","ARUK-2015DDI-OX","G0502157","R01 AG048769","MR/M013553/1","MR/K015397/1","ARUK-PG2013-22","ARUK-PG2016B-6","R01 NS100366","MR/K026992/1","RF1 AG057575","M507","PG/15/44/31574","ARUK-NCG2013A-3","ARUK-PPG2016A-3","NF-SI-0617-10150","ARUK-PhD2013-18","ARUK-SRF2013-4","MR/K017047/1","PG/15/92/31813","ART-PG2011-1","NF-SI-0515-10044","ARUK-NAS2016B-1","CZB/4/517","SBF001\\1012","PG/12/31/29527","NC/K001744/1","G0900652","RF1 NS110049","ARUK-PG2015-12","ARUK-PG2015-11","PPA2016/01","MR/R014140/1","G0500247","PPA2016/02","1355226","ARUK-IRG2014-10","MC_PC_14095","R155-2016-552","TSA15LECT05","MR/L003384/1","MR/L023784/2","MR/L023784/1","ARUK-PhD2015-15","G0400074","G1100540"],"pubmed_authors":["Carare RO","Kehoe PG","Love S","McCabe C","Granata A","Cader MZ","Goense J","Nedergaard M","Meakin PJ","McColl BW","Williams A","Work LM","Williams SCR","Kalaria RN","Wang T","Bath PM","van Agtmael T","Berwick J","Duncombe J","Lawrence CB","Touyz RM","Miller A","Farr TD","Macrae IM","Smith C","Horsburgh K","Markus HS","Lockhart A","Wardlaw JM","Allan SM","Joutel A","Davis JB","Hawkes CA","Hainsworth AH","Saksida LM","Quinn TJ","Smith KJ","Macleod MR","Hall CN","O'Sullivan M","Harvey A","Rajani R","Ashford MLJ","Fowler JH","Trueman RC","Brown R"],"additional_accession":[]},"is_claimable":false,"name":"Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.","description":"Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2020-10-31T08:05:37Z","creation":"2019-08-24T07:03:44Z"},"accession":"S-EPMC6700732","cross_references":{"pubmed":["29712883"],"doi":["10.1042/cs20171620","10.1042/CS20171620"]}}