{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kapitansky O"],"funding":["Israel Science Foundation","ERA NET Neuron"],"pagination":["321-340"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6702513"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(3)"],"pubmed_abstract":["Activity-dependent neuroprotective protein (ADNP) is essential for embryonic development with ADNP mutations leading to syndromic autism, coupled with intellectual disabilities and motor developmental delays. Here, mining human muscle gene-expression databases, we have investigated the association of ADNP transcripts with muscle aging. We discovered increased ADNP and its paralogue ADNP2 expression in the vastus lateralis muscle of aged compared to young subjects, as well as altered expression of the ADNP and the ADNP2 genes in bicep brachii muscle of elderly people, in a sex-dependent manner. Prolonged exercise resulted in decreased ADNP expression, and increased ADNP2 expression in an age-dependent manner in the vastus lateralis muscle. ADNP expression level was further correlated with 4"],"journal":["GeroScience"],"pubmed_title":["ADNP differentially interact with genes/proteins in correlation with aging: a novel marker for muscle aging."],"pmcid":["PMC6702513"],"funding_grant_id":["1424/14","AUTISYN"],"pubmed_authors":["Gozes I","Kapitansky O"],"additional_accession":[]},"is_claimable":false,"name":"ADNP differentially interact with genes/proteins in correlation with aging: a novel marker for muscle aging.","description":"Activity-dependent neuroprotective protein (ADNP) is essential for embryonic development with ADNP mutations leading to syndromic autism, coupled with intellectual disabilities and motor developmental delays. Here, mining human muscle gene-expression databases, we have investigated the association of ADNP transcripts with muscle aging. We discovered increased ADNP and its paralogue ADNP2 expression in the vastus lateralis muscle of aged compared to young subjects, as well as altered expression of the ADNP and the ADNP2 genes in bicep brachii muscle of elderly people, in a sex-dependent manner. Prolonged exercise resulted in decreased ADNP expression, and increased ADNP2 expression in an age-dependent manner in the vastus lateralis muscle. ADNP expression level was further correlated with 4","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2025-06-01T04:16:27.583Z","creation":"2019-09-05T07:01:01Z"},"accession":"S-EPMC6702513","cross_references":{"pubmed":["31264075"],"doi":["10.1007/s11357-019-00079-x"]}}