{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Govers LC"],"funding":["National Institute of Diabetes and Digestive and Kidney Diseases","NIDDK NIH HHS","National Institutes of Health"],"pagination":["10383-10392"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6704459"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(9)"],"pubmed_abstract":["Hypospadias, a developmental defect of the penis, is one of the most common congenital malformations in humans. Its incidence has rapidly increased over recent decades, and this has been largely attributed to our increased exposure to endocrine-disrupting chemicals. Penis development is primarily an androgen-driven process; however, estrogen and xenoestrogens are known to affect penis development in both humans and mice. Here, we investigated the role of estrogen in the developing penis. Using a novel penis culture system, we showed that exogenous estrogen directly targets the developing penis <i>in utero</i> to cause hypospadias. In addition, we also uncovered an unexpected endogenous role for estrogen in normal postnatal penis development and showed that a loss of estrogen signaling resu"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["A critical role for estrogen signaling in penis development."],"pmcid":["PMC6704459"],"funding_grant_id":["R01DK096263","R01 DK096263"],"pubmed_authors":["Black JR","Rashoo N","Sinclair A","Risbridger GP","Mattiske DM","Phillips TR","Baskin LS","Govers LC","Pask AJ"],"additional_accession":[]},"is_claimable":false,"name":"A critical role for estrogen signaling in penis development.","description":"Hypospadias, a developmental defect of the penis, is one of the most common congenital malformations in humans. Its incidence has rapidly increased over recent decades, and this has been largely attributed to our increased exposure to endocrine-disrupting chemicals. Penis development is primarily an androgen-driven process; however, estrogen and xenoestrogens are known to affect penis development in both humans and mice. Here, we investigated the role of estrogen in the developing penis. Using a novel penis culture system, we showed that exogenous estrogen directly targets the developing penis <i>in utero</i> to cause hypospadias. In addition, we also uncovered an unexpected endogenous role for estrogen in normal postnatal penis development and showed that a loss of estrogen signaling resu","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2026-04-18T09:14:15.036Z","creation":"2020-06-25T07:27:28Z"},"accession":"S-EPMC6704459","cross_references":{"pubmed":["31225966"],"doi":["10.1096/fj.201802586RR","10.1096/fj.201802586rr"]}}