biostudies-literatureWeinholdt CBundesministerium für Bildung und ForschungDeutsche ForschungsgemeinschaftDeutsche Forschungsgemeinschaft (DE)Bundesministerium für Bildung und Forschung (DE)434https://www.ebi.ac.uk/biostudies/studies/S-EPMC6704634biostudies-literatureUnknown20(1)<h4>Background</h4>The epidermal growth factor receptor (EGFR) is a major regulator of proliferation in tumor cells. Elevated expression levels of EGFR are associated with prognosis and clinical outcomes of patients in a variety of tumor types. There are at least four splice variants of the mRNA encoding four protein isoforms of EGFR in humans, named I through IV. EGFR isoform I is the full-length protein, whereas isoforms II-IV are shorter protein isoforms. Nevertheless, all EGFR isoforms bind the epidermal growth factor (EGF). Although EGFR is an essential target of long-established and successful tumor therapeutics, the exact function and biomarker potential of alternative EGFR isoforms II-IV are unclear, motivating more in-depth analyses. Hence, we analyzed transcriptome data from glioBMC bioinformaticsPrediction of regulatory targets of alternative isoforms of the epidermal growth factor receptor in a glioblastoma cell line.PMC6704634project number 251444481 - grant number GR 3526/6project number 197267875 - grant number GR 3526/2FKZ 24/19FKZ: 16/18, 19/13, 21/25Ardell DHGrosse IKappler MKotrba JVordermark DEckert AWWeinholdt CWichmann HfalsePrediction of regulatory targets of alternative isoforms of the epidermal growth factor receptor in a glioblastoma cell line.<h4>Background</h4>The epidermal growth factor receptor (EGFR) is a major regulator of proliferation in tumor cells. Elevated expression levels of EGFR are associated with prognosis and clinical outcomes of patients in a variety of tumor types. There are at least four splice variants of the mRNA encoding four protein isoforms of EGFR in humans, named I through IV. EGFR isoform I is the full-length protein, whereas isoforms II-IV are shorter protein isoforms. Nevertheless, all EGFR isoforms bind the epidermal growth factor (EGF). Although EGFR is an essential target of long-established and successful tumor therapeutics, the exact function and biomarker potential of alternative EGFR isoforms II-IV are unclear, motivating more in-depth analyses. Hence, we analyzed transcriptome data from glio2019-01-01T00:00:00Z2019 Aug2026-05-01T04:49:13.821Z2019-08-26T07:04:17ZS-EPMC67046343143884710.1186/s12859-019-2944-9