{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Phan QT"],"funding":["Thrasher Research Fund","Li Ka Shing Foundation","Wellcome Trust"],"pagination":["737"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6704683"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["<h4>Background</h4>Brainstem encephalitis is a serious complication of hand foot and mouth disease (HFMD) in children. Autonomic nervous system (ANS) dysregulation and hypertension may occur, sometimes progressing to cardiopulmonary failure and death. Vietnamese national guidelines recommend use of milrinone if ANS dysregulation with Stage 2 hypertension develops. We wished to investigate whether magnesium sulfate (MgSO<sub>4</sub>) improved outcomes in children with HFMD if used earlier in the evolution of the ANS dysregulation (Stage 1 hypertension).<h4>Methods</h4>During a regional epidemic we conducted a randomized, double-blind, placebo-controlled trial of MgSO<sub>4</sub> in children with HFMD, ANS dysregulation and Stage 1 hypertension, at the Hospital for Tropical Diseases in Ho Ch"],"journal":["BMC infectious diseases"],"pubmed_title":["Assessing the efficacy and safety of magnesium sulfate for management of autonomic nervous system dysregulation in Vietnamese children with severe hand foot and mouth disease."],"pmcid":["PMC6704683"],"funding_grant_id":["204904/Z/16/Z","LG27","TRF 11756"],"pubmed_authors":["Le NNT","Nguyen TD","Phung LK","Merson L","Tran QT","Geskus R","Le TPK","van Doorn HR","Wills B","Phan QT","Nguyen BN","Nguyen HT","Nguyen TTM","Nguyen CVV","Truong KH","Sabanathan S","Van Le T","Pham GT","Huynh VNT","Nguyen DTP","Huynh TT"],"additional_accession":[]},"is_claimable":false,"name":"Assessing the efficacy and safety of magnesium sulfate for management of autonomic nervous system dysregulation in Vietnamese children with severe hand foot and mouth disease.","description":"<h4>Background</h4>Brainstem encephalitis is a serious complication of hand foot and mouth disease (HFMD) in children. Autonomic nervous system (ANS) dysregulation and hypertension may occur, sometimes progressing to cardiopulmonary failure and death. Vietnamese national guidelines recommend use of milrinone if ANS dysregulation with Stage 2 hypertension develops. We wished to investigate whether magnesium sulfate (MgSO<sub>4</sub>) improved outcomes in children with HFMD if used earlier in the evolution of the ANS dysregulation (Stage 1 hypertension).<h4>Methods</h4>During a regional epidemic we conducted a randomized, double-blind, placebo-controlled trial of MgSO<sub>4</sub> in children with HFMD, ANS dysregulation and Stage 1 hypertension, at the Hospital for Tropical Diseases in Ho Ch","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2026-05-01T04:49:29.032Z","creation":"2019-08-26T07:04:19Z"},"accession":"S-EPMC6704683","cross_references":{"pubmed":["31438878"],"doi":["10.1186/s12879-019-4356-x"]}}