{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Schlundt C"],"funding":["Bundesministerium für Bildung und Frauen","Deutsche Forschungsgemeinschaft"],"pubmed_abstract":["There is increasing evidence that T lymphocytes play a key role in controlling endogenous regeneration. Regeneration appears to be impaired in case of local accumulation of CD8+ effector T cells (T<sub>EFF</sub>), impairing endogenous regeneration by increasing a primary \"useful\" inflammation toward a damaging level. Thus, rescuing regeneration by regulating the heightened pro-inflammatory reaction employing regulatory CD4+ T (T<sub>Reg</sub>) cells could represent an immunomodulatory option to enhance healing. Hypothesis was that CD4+ T<sub>Reg</sub> might counteract undesired effects of CD8+ T<sub>EFF</sub>. Using adoptive T<sub>Reg</sub> transfer, bone healing was consistently improved in mice possessing an inexperienced immune system with low amounts of CD8+ T<sub>EFF</sub>. In contras"],"journal":["Frontiers in immunology"],"pagination":["1954"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6706871"],"repository":["biostudies-literature"],"pubmed_title":["Individual Effector/Regulator T Cell Ratios Impact Bone Regeneration."],"pmcid":["PMC6706871"],"pubmed_authors":["Volk HD","Samans B","Schmidt-Bleek K","Geissler S","Mardian S","Duda GN","Schlundt C","Reinke S","Kleber C","Bucher CH","Dahne M","Giannini C","Baron U"],"additional_accession":[]},"is_claimable":false,"name":"Individual Effector/Regulator T Cell Ratios Impact Bone Regeneration.","description":"There is increasing evidence that T lymphocytes play a key role in controlling endogenous regeneration. Regeneration appears to be impaired in case of local accumulation of CD8+ effector T cells (T<sub>EFF</sub>), impairing endogenous regeneration by increasing a primary \"useful\" inflammation toward a damaging level. Thus, rescuing regeneration by regulating the heightened pro-inflammatory reaction employing regulatory CD4+ T (T<sub>Reg</sub>) cells could represent an immunomodulatory option to enhance healing. Hypothesis was that CD4+ T<sub>Reg</sub> might counteract undesired effects of CD8+ T<sub>EFF</sub>. Using adoptive T<sub>Reg</sub> transfer, bone healing was consistently improved in mice possessing an inexperienced immune system with low amounts of CD8+ T<sub>EFF</sub>. In contras","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2025-04-26T18:23:28.259Z","creation":"2019-09-05T07:01:37Z"},"accession":"S-EPMC6706871","cross_references":{"pubmed":["31475013"],"doi":["10.3389/fimmu.2019.01954"]}}