biostudies-literatureUnknown10Schlundt CBundesministerium für Bildung und FrauenDeutsche ForschungsgemeinschaftThere is increasing evidence that T lymphocytes play a key role in controlling endogenous regeneration. Regeneration appears to be impaired in case of local accumulation of CD8+ effector T cells (T<sub>EFF</sub>), impairing endogenous regeneration by increasing a primary "useful" inflammation toward a damaging level. Thus, rescuing regeneration by regulating the heightened pro-inflammatory reaction employing regulatory CD4+ T (T<sub>Reg</sub>) cells could represent an immunomodulatory option to enhance healing. Hypothesis was that CD4+ T<sub>Reg</sub> might counteract undesired effects of CD8+ T<sub>EFF</sub>. Using adoptive T<sub>Reg</sub> transfer, bone healing was consistently improved in mice possessing an inexperienced immune system with low amounts of CD8+ T<sub>EFF</sub>. In contrasFrontiers in immunology1954https://www.ebi.ac.uk/biostudies/studies/S-EPMC6706871biostudies-literatureIndividual Effector/Regulator T Cell Ratios Impact Bone Regeneration.PMC6706871Volk HDSamans BSchmidt-Bleek KGeissler SMardian SDuda GNSchlundt CReinke SKleber CBucher CHDahne MGiannini CBaron UfalseIndividual Effector/Regulator T Cell Ratios Impact Bone Regeneration.There is increasing evidence that T lymphocytes play a key role in controlling endogenous regeneration. Regeneration appears to be impaired in case of local accumulation of CD8+ effector T cells (T<sub>EFF</sub>), impairing endogenous regeneration by increasing a primary "useful" inflammation toward a damaging level. Thus, rescuing regeneration by regulating the heightened pro-inflammatory reaction employing regulatory CD4+ T (T<sub>Reg</sub>) cells could represent an immunomodulatory option to enhance healing. Hypothesis was that CD4+ T<sub>Reg</sub> might counteract undesired effects of CD8+ T<sub>EFF</sub>. Using adoptive T<sub>Reg</sub> transfer, bone healing was consistently improved in mice possessing an inexperienced immune system with low amounts of CD8+ T<sub>EFF</sub>. In contras2019-01-01T00:00:00Z20192025-04-26T18:23:28.259Z2019-09-05T07:01:37ZS-EPMC67068713147501310.3389/fimmu.2019.01954