{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li X"],"funding":["National Natural Sciences Grants China","Beijing Natural Sciences Foundation"],"pagination":["267"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6708236"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["<h4>Background</h4>To investigate the therapeutic effect of intercellular adhesion molecule (ICAM)-1-modified mesenchymal stem cells (MSCs) in a mouse model of inflammatory bowel disease (IBD) induced by dextran sulfate sodium.<h4>Methods</h4>Primary MSCs and ICAM-1-overexpressing MSCs (C3 cells) were generated in vitro. The IBD mouse model was induced with drinking water containing dextran sulfate sodium for 7 days. For stem cell therapy, mice were randomly assigned to six experimental groups: the control group, IBD group, primary MSC group, C3 group, C3-vector group, and C3-ICAM-1 group. Mice were given a single injection of 1 × 10<sup>6</sup> primary MSCs or gene-modified MSCs via the tail vein on day 3 of DDS administration. The general conditions of the mice in each group were observe"],"journal":["Stem cell research & therapy"],"pubmed_title":["Intercellular adhesion molecule-1 enhances the therapeutic effects of MSCs in a dextran sulfate sodium-induced colitis models by promoting MSCs homing to murine colons and spleens."],"pmcid":["PMC6708236"],"funding_grant_id":["81500083","81871771","81572159","7192203","7182123"],"pubmed_authors":["Li X","Mao N","Wang Q","Zhu H","Wang H","Ning SB","Zhao ZD","Wu CT","Wang YX","Ding L"],"additional_accession":[]},"is_claimable":false,"name":"Intercellular adhesion molecule-1 enhances the therapeutic effects of MSCs in a dextran sulfate sodium-induced colitis models by promoting MSCs homing to murine colons and spleens.","description":"<h4>Background</h4>To investigate the therapeutic effect of intercellular adhesion molecule (ICAM)-1-modified mesenchymal stem cells (MSCs) in a mouse model of inflammatory bowel disease (IBD) induced by dextran sulfate sodium.<h4>Methods</h4>Primary MSCs and ICAM-1-overexpressing MSCs (C3 cells) were generated in vitro. The IBD mouse model was induced with drinking water containing dextran sulfate sodium for 7 days. For stem cell therapy, mice were randomly assigned to six experimental groups: the control group, IBD group, primary MSC group, C3 group, C3-vector group, and C3-ICAM-1 group. Mice were given a single injection of 1 × 10<sup>6</sup> primary MSCs or gene-modified MSCs via the tail vein on day 3 of DDS administration. The general conditions of the mice in each group were observe","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2025-04-26T02:07:32.941Z","creation":"2019-09-05T07:01:54Z"},"accession":"S-EPMC6708236","cross_references":{"pubmed":["31443680"],"doi":["10.1186/s13287-019-1384-9"]}}