biostudies-literatureUnknownBauer RJIn this second tutorial on NONMEM, examples of typical PK/PD modeling problems that occur in the pharmaceutical field will be presented, and which the reader can utilize as a template for his own modeling endeavors. Each of the problems presented are challenging in some way, and the logic behind setting up each problem is discussed. Logical concepts of the problem itself as well as the technical aspect of how to set it up in NONMEM are described and demonstrated. The concepts behind the various estimation algorithms will first be described to allow the user a better understanding of how to use them. This article is protected by copyright. All rights reserved.CPT: pharmacometrics & systems pharmacologyhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC6709422biostudies-literatureNONMEM Tutorial Part II: Estimation Methods and Advanced Examples.PMC6709422Bauer RJfalseNONMEM Tutorial Part II: Estimation Methods and Advanced Examples.In this second tutorial on NONMEM, examples of typical PK/PD modeling problems that occur in the pharmaceutical field will be presented, and which the reader can utilize as a template for his own modeling endeavors. Each of the problems presented are challenging in some way, and the logic behind setting up each problem is discussed. Logical concepts of the problem itself as well as the technical aspect of how to set it up in NONMEM are described and demonstrated. The concepts behind the various estimation algorithms will first be described to allow the user a better understanding of how to use them. This article is protected by copyright. All rights reserved.2019-01-01T00:00:00Z2019 May2024-11-15T15:35:38.882Z2019-09-05T07:01:57ZS-EPMC67094223104455810.1002/psp4.12422