{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["38(1)"],"submitter":["Palmisano P"],"pubmed_abstract":["Prior studies have suggested that a substantial number of eligible heart failure (HF) patients fail to receive β-blocker therapy, or receive it at a suboptimal dose. The aim of this study is to assess the benefit of a predefined management program designed for β-blocker up-titration, evaluating the synergistic effect of cardiac resynchronization therapy (CRT) and β-blockers in a HF population. The Resynchronization Therapy and β-Blocker Titration (RESTORE) study is a prospective, case-control, multicenter cohort study designed to test the hypothesis that a β-blocker up-titration strategy based on a predefined management program maximizes the beneficial effect of CRT, increasing the number of patients reaching the target dose of β-blockers and improving their clinical outcome. All study pat"],"journal":["Clinical cardiology"],"pagination":["2-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6711010"],"repository":["biostudies-literature"],"pubmed_title":["Evaluation of synergistic effects of resynchronization therapy and a β-blocker up-titration strategy based on a predefined patient-management program: the RESTORE study."],"pmcid":["PMC6711010"],"pubmed_authors":["Ruocco A","Valsecchi S","Calo L","Bianchi V","Palmisano P","Accogli M","D'Onofrio A","Del Giorno G","Gronda E","Malacrida M","Ammendola E","Rapacciuolo A"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of synergistic effects of resynchronization therapy and a β-blocker up-titration strategy based on a predefined patient-management program: the RESTORE study.","description":"Prior studies have suggested that a substantial number of eligible heart failure (HF) patients fail to receive β-blocker therapy, or receive it at a suboptimal dose. The aim of this study is to assess the benefit of a predefined management program designed for β-blocker up-titration, evaluating the synergistic effect of cardiac resynchronization therapy (CRT) and β-blockers in a HF population. The Resynchronization Therapy and β-Blocker Titration (RESTORE) study is a prospective, case-control, multicenter cohort study designed to test the hypothesis that a β-blocker up-titration strategy based on a predefined management program maximizes the beneficial effect of CRT, increasing the number of patients reaching the target dose of β-blockers and improving their clinical outcome. All study pat","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jan","modification":"2025-04-04T07:41:57.824Z","creation":"2019-09-05T07:02:10Z"},"accession":"S-EPMC6711010","cross_references":{"pubmed":["25580847"],"doi":["10.1002/clc.22352"]}}