biostudies-literatureQiu MHNational Natural Science Foundation of ChinaNINDS NIH HHSNational Institutes of HealthNIH HHS2525-2535https://www.ebi.ac.uk/biostudies/studies/S-EPMC6713786biostudies-literatureUnknown224(7)The midbrain dopamine system via the dorsal and ventral striatum regulates a wide range of behaviors. To dissect the role of dopaminergic projections to the dorsal striatum (nigrostriatal projection) and ventral striatum (mesolimbic projection) in sleep-wake behavior, we selectively chemogenetically stimulated nigrostriatal or mesolimbic projections and examined the resulting effects on sleep in rats. Stimulation of nigrostriatal pathways increased sleep and EEG delta power, while stimulation of mesolimbic pathways decreased sleep and reduced cortical EEG power. These results indicate that midbrain dopamine signaling in the dorsal or ventral striatum promotes sleep or wake, respectively.Brain structure & functionNigrostriatal and mesolimbic control of sleep-wake behavior in rat.PMC67137863117104981771430R01 NS061841NS095986NS061841R01 NS095986Chen MCLu JZhong ZGQiu MHfalseNigrostriatal and mesolimbic control of sleep-wake behavior in rat.The midbrain dopamine system via the dorsal and ventral striatum regulates a wide range of behaviors. To dissect the role of dopaminergic projections to the dorsal striatum (nigrostriatal projection) and ventral striatum (mesolimbic projection) in sleep-wake behavior, we selectively chemogenetically stimulated nigrostriatal or mesolimbic projections and examined the resulting effects on sleep in rats. Stimulation of nigrostriatal pathways increased sleep and EEG delta power, while stimulation of mesolimbic pathways decreased sleep and reduced cortical EEG power. These results indicate that midbrain dopamine signaling in the dorsal or ventral striatum promotes sleep or wake, respectively.2019-01-01T00:00:00Z2019 Sep2024-11-21T11:04:28.901Z2020-09-04T07:03:49ZS-EPMC67137863132496910.1007/s00429-019-01921-w