{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Godefroy A"],"funding":["Telethon"],"pagination":["6499-6503"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6714136"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(9)"],"pubmed_abstract":["In the search of a better enzyme therapy in Pompe disease, the conjugation of mannose 6-phosphonates to the recombinant enzyme appeared as an enhancer of its efficacy. Here, we demonstrated that the increased efficacy of the conjugated enzyme is partly due to a higher intracellular maturation because of its insensitiveness to acid phosphatases during the routing to lysosomes."],"journal":["Journal of cellular and molecular medicine"],"pubmed_title":["Mannose 6-phosphonate labelling: A key for processing the therapeutic enzyme in Pompe disease."],"pmcid":["PMC6714136"],"funding_grant_id":["GTB12001"],"pubmed_authors":["Charbonne HV","Sacconi S","Garcia M","Da Silva A","Schoser B","Morere A","Caillaud C","Basile I","Gary-Bobo M","Maynadier M","Daurat M","El Cheikh K","Godefroy A"],"additional_accession":[]},"is_claimable":false,"name":"Mannose 6-phosphonate labelling: A key for processing the therapeutic enzyme in Pompe disease.","description":"In the search of a better enzyme therapy in Pompe disease, the conjugation of mannose 6-phosphonates to the recombinant enzyme appeared as an enhancer of its efficacy. Here, we demonstrated that the increased efficacy of the conjugated enzyme is partly due to a higher intracellular maturation because of its insensitiveness to acid phosphatases during the routing to lysosomes.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2021-02-20T12:22:09Z","creation":"2019-09-08T07:01:25Z"},"accession":"S-EPMC6714136","cross_references":{"pubmed":["31293082"],"doi":["10.1111/jcmm.14516"]}}