biostudies-literatureGodefroy ATelethon6499-6503https://www.ebi.ac.uk/biostudies/studies/S-EPMC6714136biostudies-literatureUnknown23(9)In the search of a better enzyme therapy in Pompe disease, the conjugation of mannose 6-phosphonates to the recombinant enzyme appeared as an enhancer of its efficacy. Here, we demonstrated that the increased efficacy of the conjugated enzyme is partly due to a higher intracellular maturation because of its insensitiveness to acid phosphatases during the routing to lysosomes.Journal of cellular and molecular medicineMannose 6-phosphonate labelling: A key for processing the therapeutic enzyme in Pompe disease.PMC6714136GTB12001Charbonne HVSacconi SGarcia MDa Silva ASchoser BMorere ACaillaud CBasile IGary-Bobo MMaynadier MDaurat MEl Cheikh KGodefroy AfalseMannose 6-phosphonate labelling: A key for processing the therapeutic enzyme in Pompe disease.In the search of a better enzyme therapy in Pompe disease, the conjugation of mannose 6-phosphonates to the recombinant enzyme appeared as an enhancer of its efficacy. Here, we demonstrated that the increased efficacy of the conjugated enzyme is partly due to a higher intracellular maturation because of its insensitiveness to acid phosphatases during the routing to lysosomes.2019-01-01T00:00:00Z2019 Sep2021-02-20T12:22:09Z2019-09-08T07:01:25ZS-EPMC67141363129308210.1111/jcmm.14516