biostudies-literatureTyurina YYRussian academic excellence projectNIAID NIH HHSNHLBI NIH HHSNINDS NIH HHSNCI NIH HHSNIHNIGMS NIH HHS93-107https://www.ebi.ac.uk/biostudies/studies/S-EPMC6714565biostudies-literatureUnknown221Aerobic life is based on numerous metabolic oxidation reactions as well as biosynthesis of oxygenated signaling compounds. Among the latter are the myriads of oxygenated lipids including a well-studied group of polyunsaturated fatty acids (PUFA) - octadecanoids, eicosanoids, and docosanoids. During the last two decades, remarkable progress in liquid-chromatography-mass spectrometry has led to significant progress in the characterization of oxygenated PUFA-containing phospholipids, thus designating the emergence of a new field of lipidomics, redox lipidomics. Although non-enzymatic free radical reactions of lipid peroxidation have been mostly associated with the aberrant metabolism typical of acute injury or chronic degenerative processes, newly accumulated evidence suggests that enzymaticaChemistry and physics of lipids"Redox lipidomics technology: Looking for a needle in a haystack".PMC6714565NS061817R01 GM113908U19 AI068021NS076511R01 CA165065HL114453-06P30 CA010815R01 NS076511P01 HL114453CA165065-06U19AI068021R01 NS061817Anthonymuthu TSparvero LJSun WHe RTyurina YYKhaitovich PKagan VEBaynard MLVladimirov YABayır HAmoscato AATyurin VANesterova AMGabrilovich DIfalse"Redox lipidomics technology: Looking for a needle in a haystack".Aerobic life is based on numerous metabolic oxidation reactions as well as biosynthesis of oxygenated signaling compounds. Among the latter are the myriads of oxygenated lipids including a well-studied group of polyunsaturated fatty acids (PUFA) - octadecanoids, eicosanoids, and docosanoids. During the last two decades, remarkable progress in liquid-chromatography-mass spectrometry has led to significant progress in the characterization of oxygenated PUFA-containing phospholipids, thus designating the emergence of a new field of lipidomics, redox lipidomics. Although non-enzymatic free radical reactions of lipid peroxidation have been mostly associated with the aberrant metabolism typical of acute injury or chronic degenerative processes, newly accumulated evidence suggests that enzymatica2019-01-01T00:00:00Z2019 Jul2025-04-04T22:11:51.927Z2019-09-05T07:02:37ZS-EPMC67145653092833810.1016/j.chemphyslip.2019.03.012