{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sanchez JA"],"funding":["Ministry of Science, Innovation and Universities","Universidad Nacional del Litoral","Agencia Nacional de Promoción Científica y Tecnológica","Ministerio de Ciencia e Innovación"],"pagination":["e1008133"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6715248"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(8)"],"pubmed_abstract":["Coordinated intra- and inter-organ growth during animal development is essential to ensure a correctly proportioned individual. The Drosophila wing has been a valuable model system to reveal the existence of a stress response mechanism involved in the coordination of growth between adjacent cell populations and to identify a role of the fly orthologue of p53 (Dmp53) in this process. Here we identify the molecular mechanisms used by Dmp53 to regulate growth and proliferation in a non-autonomous manner. First, Dmp53-mediated transcriptional induction of Eiger, the fly orthologue of TNFα ligand, leads to the cell-autonomous activation of JNK. Second, two distinct signaling events downstream of the Eiger/JNK axis are induced in order to independently regulate tissue size and cell number in adj"],"journal":["PLoS genetics"],"pubmed_title":["Eiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in Drosophila."],"pmcid":["PMC6715248"],"funding_grant_id":["SIGNAGROWTH-BFU2013-44485","PICT-2015-0032","CAI+D","INTERGROWTH-BFU2016-77587-P","PICT-2014-1412"],"pubmed_authors":["Ariel F","Dekanty A","Milan M","Mesquita D","Ingaramo MC","Sanchez JA"],"additional_accession":[]},"is_claimable":false,"name":"Eiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in Drosophila.","description":"Coordinated intra- and inter-organ growth during animal development is essential to ensure a correctly proportioned individual. The Drosophila wing has been a valuable model system to reveal the existence of a stress response mechanism involved in the coordination of growth between adjacent cell populations and to identify a role of the fly orthologue of p53 (Dmp53) in this process. Here we identify the molecular mechanisms used by Dmp53 to regulate growth and proliferation in a non-autonomous manner. First, Dmp53-mediated transcriptional induction of Eiger, the fly orthologue of TNFα ligand, leads to the cell-autonomous activation of JNK. Second, two distinct signaling events downstream of the Eiger/JNK axis are induced in order to independently regulate tissue size and cell number in adj","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2026-05-04T14:58:34.734Z","creation":"2019-09-14T07:04:08Z"},"accession":"S-EPMC6715248","cross_references":{"pubmed":["31425511"],"doi":["10.1371/journal.pgen.1008133"]}}