biostudies-literatureSanchez JAMinistry of Science, Innovation and UniversitiesUniversidad Nacional del LitoralAgencia Nacional de Promoción Científica y TecnológicaMinisterio de Ciencia e Innovacióne1008133https://www.ebi.ac.uk/biostudies/studies/S-EPMC6715248biostudies-literatureUnknown15(8)Coordinated intra- and inter-organ growth during animal development is essential to ensure a correctly proportioned individual. The Drosophila wing has been a valuable model system to reveal the existence of a stress response mechanism involved in the coordination of growth between adjacent cell populations and to identify a role of the fly orthologue of p53 (Dmp53) in this process. Here we identify the molecular mechanisms used by Dmp53 to regulate growth and proliferation in a non-autonomous manner. First, Dmp53-mediated transcriptional induction of Eiger, the fly orthologue of TNFα ligand, leads to the cell-autonomous activation of JNK. Second, two distinct signaling events downstream of the Eiger/JNK axis are induced in order to independently regulate tissue size and cell number in adjPLoS geneticsEiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in Drosophila.PMC6715248SIGNAGROWTH-BFU2013-44485PICT-2015-0032CAI+DINTERGROWTH-BFU2016-77587-PPICT-2014-1412Ariel FDekanty AMilan MMesquita DIngaramo MCSanchez JAfalseEiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in Drosophila.Coordinated intra- and inter-organ growth during animal development is essential to ensure a correctly proportioned individual. The Drosophila wing has been a valuable model system to reveal the existence of a stress response mechanism involved in the coordination of growth between adjacent cell populations and to identify a role of the fly orthologue of p53 (Dmp53) in this process. Here we identify the molecular mechanisms used by Dmp53 to regulate growth and proliferation in a non-autonomous manner. First, Dmp53-mediated transcriptional induction of Eiger, the fly orthologue of TNFα ligand, leads to the cell-autonomous activation of JNK. Second, two distinct signaling events downstream of the Eiger/JNK axis are induced in order to independently regulate tissue size and cell number in adj2019-01-01T00:00:00Z2019 Aug2026-05-04T14:58:34.734Z2019-09-14T07:04:08ZS-EPMC67152483142551110.1371/journal.pgen.1008133