{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Chirshev E"],"funding":["Loma Linda University","Loma Linda University, Division of Anatomy"],"pubmed_abstract":["Abnormal regulation and expression of microRNAs (miRNAs) has been documented in various diseases including cancer. The miRNA let-7 (MIRLET7) family controls developmental timing and differentiation. Let-7 loss contributes to carcinogenesis via an increase in its target oncogenes and stemness factors. Let-7 targets include genes regulating the cell cycle, cell signaling, and maintenance of differentiation. It is categorized as a tumor suppressor because it reduces cancer aggressiveness, chemoresistance, and radioresistance. However, in rare situations let-7 acts as an oncogene, increasing cancer migration, invasion, chemoresistance, and expression of genes associated with progression and metastasis. Here, we review let-7 function as tumor suppressor and oncogene, considering let-7 as a pote"],"journal":["Clinical and translational medicine"],"pagination":["24"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6715759"],"repository":["biostudies-literature"],"pubmed_title":["Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer."],"pmcid":["PMC6715759"],"pubmed_authors":["Ioffe YJ","Unternaehrer JJ","Chirshev E","Oberg KC"],"additional_accession":[]},"is_claimable":false,"name":"Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer.","description":"Abnormal regulation and expression of microRNAs (miRNAs) has been documented in various diseases including cancer. The miRNA let-7 (MIRLET7) family controls developmental timing and differentiation. Let-7 loss contributes to carcinogenesis via an increase in its target oncogenes and stemness factors. Let-7 targets include genes regulating the cell cycle, cell signaling, and maintenance of differentiation. It is categorized as a tumor suppressor because it reduces cancer aggressiveness, chemoresistance, and radioresistance. However, in rare situations let-7 acts as an oncogene, increasing cancer migration, invasion, chemoresistance, and expression of genes associated with progression and metastasis. Here, we review let-7 function as tumor suppressor and oncogene, considering let-7 as a pote","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2025-04-18T18:02:29.39Z","creation":"2019-09-24T07:05:33Z"},"accession":"S-EPMC6715759","cross_references":{"pubmed":["31468250"],"doi":["10.1186/s40169-019-0240-y"]}}