{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dong S"],"funding":["NIAID NIH HHS","National Institutes of Health"],"pagination":["e0007681"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6716673"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(8)"],"pubmed_abstract":["Zika virus (ZIKV), an emerging arbovirus belonging to the genus Flavivirus, is transmitted by Aedes mosquitoes. ZIKV infection can cause microcephaly of newborn babies and Guillain-Barré syndrome in adults. Because no licensed vaccine or specific antiviral treatment is available for ZIKV infection, the most commonly used approach to control the spread of ZIKV is suppression of the mosquito vector population. A novel proposed strategy to block arthropod virus (arbovirus) transmission is based on the chemical inhibition of virus infection in mosquitoes. However, only a few drugs and compounds have been tested with such properties. Here we present a comprehensive screen of 55 FDA-approved anti-flaviviral drugs for potential anti-ZIKV and mosquitocidal activity. Four drugs (auranofin, actinomy"],"journal":["PLoS neglected tropical diseases"],"pubmed_title":["Identification of anti-flaviviral drugs with mosquitocidal and anti-Zika virus activity in Aedes aegypti."],"pmcid":["PMC6716673"],"funding_grant_id":["R01AI101431","R01 AI101431","R01 AI122743","R01AI122743"],"pubmed_authors":["Kang S","Dimopoulos G","Dong S"],"additional_accession":[]},"is_claimable":false,"name":"Identification of anti-flaviviral drugs with mosquitocidal and anti-Zika virus activity in Aedes aegypti.","description":"Zika virus (ZIKV), an emerging arbovirus belonging to the genus Flavivirus, is transmitted by Aedes mosquitoes. ZIKV infection can cause microcephaly of newborn babies and Guillain-Barré syndrome in adults. Because no licensed vaccine or specific antiviral treatment is available for ZIKV infection, the most commonly used approach to control the spread of ZIKV is suppression of the mosquito vector population. A novel proposed strategy to block arthropod virus (arbovirus) transmission is based on the chemical inhibition of virus infection in mosquitoes. However, only a few drugs and compounds have been tested with such properties. Here we present a comprehensive screen of 55 FDA-approved anti-flaviviral drugs for potential anti-ZIKV and mosquitocidal activity. Four drugs (auranofin, actinomy","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2025-04-19T16:45:11.23Z","creation":"2019-09-14T07:04:16Z"},"accession":"S-EPMC6716673","cross_references":{"pubmed":["31430351"],"doi":["10.1371/journal.pntd.0007681"]}}