biostudies-literatureUnknownIderaabdullah FYNIDDK NIH HHSNIEHS NIH HHSVitamin D is an essential nutrient that is metabolized in the body to generate an active metabolite (1,25(OH)2D) with hormone-like activity and highly diverse roles in cellular function. Vitamin D deficiency (VDD) is a prevalent but easily preventable nutritional disturbance. Emerging evidence demonstrates the importance of sufficient vitamin D concentrations during fetal life with deficiencies leading to long-term effects into adulthood. Here, we provide a detailed review and perspective of evidence for the role of maternal VDD in offspring long term health, particularly as it relates to Developmental Origins of Health and Disease (DOHaD). We focus on roles in neurobehavioral and cardiometabolic disorders in humans and highlight recent findings from zebrafish and rodent models that probe The Journal of endocrinologyJOE-18-0541.R2https://www.ebi.ac.uk/biostudies/studies/S-EPMC6717694biostudies-literatureMaternal vitamin D deficiency and developmental origins of health and disease (DOHaD).PMC6717694P30 DK056350P30 ES025128K22 ES023849R01 ES025547Kullman SWIderaabdullah FYBelenchia AMPeterson CABereman MLevin EDKnuth MMahapatra DRosenfeld CSfalseMaternal vitamin D deficiency and developmental origins of health and disease (DOHaD).Vitamin D is an essential nutrient that is metabolized in the body to generate an active metabolite (1,25(OH)2D) with hormone-like activity and highly diverse roles in cellular function. Vitamin D deficiency (VDD) is a prevalent but easily preventable nutritional disturbance. Emerging evidence demonstrates the importance of sufficient vitamin D concentrations during fetal life with deficiencies leading to long-term effects into adulthood. Here, we provide a detailed review and perspective of evidence for the role of maternal VDD in offspring long term health, particularly as it relates to Developmental Origins of Health and Disease (DOHaD). We focus on roles in neurobehavioral and cardiometabolic disorders in humans and highlight recent findings from zebrafish and rodent models that probe 2019-01-01T00:00:00Z2019 Mar2025-04-22T03:26:15.641Z2020-09-05T07:12:03ZS-EPMC67176943090916710.1530/JOE-18-054110.1530/joe-18-0541