{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kloetgen A"],"funding":["American Cancer Society","National Institute for Health Research (NIHR)","National Cancer Institute","NCI NIH HHS","National Institutes of Health","American Association for Cancer Research"],"pagination":["809-824"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6718347"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(9)"],"pubmed_abstract":["Epigenetic dysregulation plays a profound role in the pathogenesis of hematological malignancies, which is often the result of somatic mutations of chromatin regulators. Previously, these mutations were largely considered to alter gene expression in two dimensions, by activating or repressing chromatin states; however, research in the last decade has highlighted the increasing impact of the 3D organization of the genome in gene regulation and disease pathogenesis. Here, we summarize the current principles of 3D chromatin organization, how the integrity of the 3D genome governs immune cell development and malignant transformation, as well as how underlying (epi-)genetic drivers of 3D chromatin alterations might act as potential novel therapeutic targets for hematological malignancies."],"journal":["Trends in immunology"],"pubmed_title":["3D Chromosomal Landscapes in Hematopoiesis and Immunity."],"pmcid":["PMC6718347"],"funding_grant_id":["P01 CA229086","RO1CA194923","R01 CA216421","C32563GG","R01 CA169784","R01 CA228135","C32587GG","R01 CA194923","RO1CA216421","RO1CA228135","PO1CA229086"],"pubmed_authors":["Kloetgen A","Thandapani P","Aifantis I","Tsirigos A"],"additional_accession":[]},"is_claimable":false,"name":"3D Chromosomal Landscapes in Hematopoiesis and Immunity.","description":"Epigenetic dysregulation plays a profound role in the pathogenesis of hematological malignancies, which is often the result of somatic mutations of chromatin regulators. Previously, these mutations were largely considered to alter gene expression in two dimensions, by activating or repressing chromatin states; however, research in the last decade has highlighted the increasing impact of the 3D organization of the genome in gene regulation and disease pathogenesis. Here, we summarize the current principles of 3D chromatin organization, how the integrity of the 3D genome governs immune cell development and malignant transformation, as well as how underlying (epi-)genetic drivers of 3D chromatin alterations might act as potential novel therapeutic targets for hematological malignancies.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2024-11-13T00:53:45.942Z","creation":"2020-09-05T07:12:00Z"},"accession":"S-EPMC6718347","cross_references":{"pubmed":["31422902"],"doi":["10.1016/j.it.2019.07.003"]}}