{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["366"],"submitter":["Thayakaran R"],"pubmed_abstract":["<h4>Objective</h4>To explore whether thyroid stimulating hormone (TSH) concentration in patients with a diagnosis of hypothyroidism is associated with increased all cause mortality and a higher risk of cardiovascular disease and fractures.<h4>Design</h4>Retrospective cohort study.<h4>Setting</h4>The Health Improvement Network (THIN), a database of electronic patient records from UK primary care.<h4>Participants</h4>Adult patients with incident hypothyroidism from 1 January 1995 to 31 December 2017.<h4>Exposure</h4>TSH concentration in patients with hypothyroidism.<h4>Main outcome measures</h4>Ischaemic heart disease, heart failure, stroke/transient ischaemic attack, atrial fibrillation, any fractures, fragility fractures, and mortality. Longitudinal TSH measurements from diagnosis to outco"],"journal":["BMJ (Clinical research ed.)"],"pagination":["l4892"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6719286"],"repository":["biostudies-literature"],"pubmed_title":["Thyroid replacement therapy, thyroid stimulating hormone concentrations, and long term health outcomes in patients with hypothyroidism: longitudinal study."],"pmcid":["PMC6719286"],"pubmed_authors":["Thayakaran R","Sumilo D","Nirantharakumar K","Torlinska B","Adderley NJ","Sainsbury C","Price M","Boelaert K","Thomas GN","Toulis KA"],"additional_accession":[]},"is_claimable":false,"name":"Thyroid replacement therapy, thyroid stimulating hormone concentrations, and long term health outcomes in patients with hypothyroidism: longitudinal study.","description":"<h4>Objective</h4>To explore whether thyroid stimulating hormone (TSH) concentration in patients with a diagnosis of hypothyroidism is associated with increased all cause mortality and a higher risk of cardiovascular disease and fractures.<h4>Design</h4>Retrospective cohort study.<h4>Setting</h4>The Health Improvement Network (THIN), a database of electronic patient records from UK primary care.<h4>Participants</h4>Adult patients with incident hypothyroidism from 1 January 1995 to 31 December 2017.<h4>Exposure</h4>TSH concentration in patients with hypothyroidism.<h4>Main outcome measures</h4>Ischaemic heart disease, heart failure, stroke/transient ischaemic attack, atrial fibrillation, any fractures, fragility fractures, and mortality. Longitudinal TSH measurements from diagnosis to outco","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2025-04-04T07:51:53.2Z","creation":"2019-09-24T07:06:18Z"},"accession":"S-EPMC6719286","cross_references":{"pubmed":["31481394"],"doi":["10.1136/bmj.l4892"]}}